摘要
急性髓系白血病(acute myeloid leukemia,AML)是一种侵袭性血液学恶性肿瘤,是由血液和骨髓中未成熟的白血病细胞积累引起的。目前的标准治疗方案是以大剂量的常规化疗进行诱导缓解,待取得完全缓解(complete remission,CR)后再进行后续治疗,以达到强化和维持治疗的作用,但此种治疗方法的预后及生存率仍不理想。对于不适合强化治疗方案的患者以及复发或难治性疾病患者,迫切需要用于替代的免疫治疗策略。在过去几年里,免疫疗法的进步使癌症治疗发生了革命性的变化。新的免疫治疗方法正在进入肿瘤学的主流,为AML的预后及生存率提供新的武器,并在AML的治疗中越来越显示出其相较于传统治疗的优势。该文将对造血干细胞移植(hematopoietic stem cell,HSC)、嵌合抗原受体T细胞(chimeric antigen receptor T-cell immunotherapy,CAR-T)、单克隆抗体药物、自然杀伤细胞(nature kill cell,NK)、树突细胞(dendritic cells,DC)疫苗这5种目前主要的免疫治疗方案的研究进展及相关分子机制进行综述。
AML(acute myeloid leukemia)is an invasive hematological malignancy caused by the accumulation of immature leukemia cells in the blood and bone marrow.It’s core treatment,induction of remission with high-dose conventional chemotherapy,followed by CR(complete remission)to achieve intensive and maintenance therapy,but the survival rate and the prognosis of the disease is still not ideal.For patients who are not suitable for intensive treatment and patients with relapsed or refractory diseases,there is an urgent need for alternative immunotherapy strategies.The progress in immunotherapy have revolutionized the cancer treatment in the past few years.New immunotherapeutics are entering the mainstream of oncology,providing new weapons for the prognosis and survival of AML,and increasingly showing its advantages for traditional treatment in the treatment of AML.Currently,there are five main immunotherapy regimens:HSC(hematopoietic stem cell),CAR-T(chimeric antigen receptor T-cell),monoclonal antibody drugs,NK(natural killer cell),DC(dendritic cell)vaccine.This paper will review the current research progress of AML immunotherapy and related molecular mechanism.
作者
李姗姗
潘慧
李茗达
崔昌浩
LI Shanshan;PAN Hui;LI Mingda;CUI Changhao(School of Life Science and Medicine,Dalian University of Technology Panjin Campus,Panjin 124221,China)
出处
《中国细胞生物学学报》
CAS
CSCD
2019年第12期2393-2405,共13页
Chinese Journal of Cell Biology
基金
辽宁省自然科学基金(批准号:20170540184)
中央高校基本科研业务费(批准号:DUT18LK30、DUT17ZD214)资助的课题.
关键词
急性髓系白血病
免疫治疗
靶向治疗
acute myeloid leukemia
immunotherapy
targeted therapy
