摘要
几十年前观察到肠道紊乱尤其是乳糜泻和炎症性肠病与IgA肾病(IgAN)有关后,便认为肠道相关的淋巴组织(GALT)失调和IgAN之间存在联系。GALT失调如基因调节、肠道失调和对饮食成分的反应可能共同作用于IgAN的发生和发展。这一假设对IgAN治疗提供了新视角,主要是针对GALT靶向治疗的糖皮质激素,也为调节饮食成分和肠道微生物提供了可能。
The connection between a dysregulated gut-associated lymphoid tissue(GALT)and IgA nephropathy(IgAN)was supposed decades ago after detecting the association between IgAN and intestinal disorders,particularly celiac and inflammatory bowel diseases.In dysregulated GALT,genetic conditioning,gut dysbiosis and reaction to diet components may play a combined role in the development and progression of IgAN.This hypothesis provides a new perspective for the treatment of IgAN,mainly aimed at glucocorticoids targeted at GALT,and also provides the possibility for regulating dietary composition and intestinal microorganisms.
作者
唐霄杨
伍刚
TANG Xiaoyang;WU Gang(Department of Nephrology,Subei People's Hospital,Yangzhou 225001,China)
出处
《现代医学》
2020年第1期150-154,共5页
Modern Medical Journal
