摘要
目的:研究特瑞普利联合舒尼替尼治疗晚期肾透明细胞癌的效果及对血管内皮生长因子(VEGF)、生长分化因子15(GDF-15)及肾功能的影响。方法:回顾性分析2019年1月至2021年1月福建医科大学附属漳州市医院收治的采用特瑞普利联合舒尼替尼治疗的20例晚期肾透明细胞癌患者。分析患者生活质量、血清VEGF、GDF-15水平、肾功能指标、T淋巴细胞亚群水平、不良反应发生情况、临床疗效。结果:治疗后,患者临床疗效的总有效率为60%;患者血清VEGF、GDF-15水平均低于治疗前,差异具有统计学意义(P<0.05);患者血肌酐(Scr)、血尿素氮(BUN)及尿白蛋白(ALB)水平均低于治疗前,差异具有统计学意义(P<0.05)。治疗前后,患者T淋巴细胞亚群水平比较,差异无统计学意义(P>0.05)。治疗后,患者生理领域、心理领域、社会关系及环境领域评分均高于治疗前,差异具有统计学意义(P<0.05)。治疗期间,患者不良反应发生率为血液学毒性35%、腹泻20%、食欲不振30%、发热20%及脱发60%。结论:特瑞普利联合舒尼替尼治疗晚期肾透明细胞癌效果明显,可有效改善VEGF、GDF-15及肾功能水平。
Objective To investigate the efficacy of trepril combined with sunitinib in the treatment of advanced renal clear cell carcinoma and its effects on vascular endothelial growth factor(VEGF),growth differentiation factor 15(GDF-15),and renal function.Methods A retrospective analysis was conducted on 20 patients with advanced renal clear cell carcinoma admitted to Zhangzhou Hospital Affiliated to Fujian Medical University from January 2019 to January 2021,who were treated with trepril combined with sunitinib.Analyze the patients'quality of life,serum VEGF,GDF-15 levels,renal function indicators,T lymphocyte subgroup levels,incidence of adverse reactions,and clinical efficacy.Results After treatment,the total effective rate of the patients'clinical efficacy was 60%.After treatment,the serum levels of VEGF and GDF-15 in patients were lower than those before treatment,with statistically significant differences(P<0.05).After treatment,the levels of serum creatinine(Scr),blood urea nitrogen(BUN),and urinary albumin(ALB)in patients were lower than those before treatment,with statistically significant differences(P<0.05).Before and after treatment,there was no statistically significant difference in the levels of T lymphocyte subsets among patients(P>0.05).After treatment,the patients'scores in the fields of physiology,psychology,social relations,and environment were higher than those before treatment,and the differences were statistically significant(P<0.05).During the treatment period,the incidence of adverse reactions in patients was 35%for hematological toxicity,20%for diarrhea,30%for loss of appetite,20%for fever,and 60%for hair loss.Conclusion The combination of trepril and sunitinib has a significant therapeutic effect on advanced renal clear cell carcinoma,and can effectively improve the levels of VEGF,GDF-15,and renal function.
作者
刘洪杰
苏陈强
林泽斌
许振强
LIU Hongjie;SU Chenqiang;LIN Zebin;XU Zhenqiang(Zhangzhou Hospital Affiliated to Fujian Medical University,FuJian ZhangZhou 363000)
出处
《深圳中西医结合杂志》
2023年第17期18-21,共4页
Shenzhen Journal of Integrated Traditional Chinese and Western Medicine
