摘要
目的:比较新旧两种糖负荷联合静脉注射胰岛素方法在冠心病(CHD)患者氟代脱氧葡萄糖(^(18)F-FDG)正电子发射型计算机断层扫描(PET/CT)心肌代谢显像中的价值。方法:回顾性分析广东省人民医院2018年4月16日至2021年4月2日收治的160例CHD患者的心肌代谢显像临床资料,比较新旧两种调糖方案的图像质量以及两种调糖方案的不良反应情况。结果:(1)38例旧方案有糖尿病(DM)或糖耐量异常的患者(A1)中,29例患者图像质量较好,9例图像质量差,其中有8例通过延迟1 h后图像可以诊断;29例新方案有DM或糖耐量异常患者的(B1)中,23例患者图像质量较好,6例图像质量差,通过延迟1 h后图像均可以诊断。A1方案中图像质量较好占比为76.3%(29/38),B1方案则为79.3%(23/29),两种方案比较,差异无统计学意义(P>0.05)。(2)旧方案无DM或糖耐量异常患者(A2)中,图像质量较好占比67.9%(38/56),新方案无DM或糖耐量异常患者(B2)中,图像质量较好占比86.5%(32/37),且所有图像均可诊断。(3)旧方案出现3例低血糖患者,新方案无患者出现低血糖不良反应,两种方案不良反应发生率比较,差异无统计学意义(P>0.05)。结论:在CHD患者^(18)F-FDG PET/CT心肌代谢显像中采用新调糖方案是可行的,且图像质量与旧方案无差异,并且不出现低血糖等不良反应。
Objective To compare the value of the old and new schemes of glucose loading combined with intravenous insulin in myocardial metabolism imaging of^(18)F-fluorodeoxyglucose(^(18)F-FDG)positron emission tomography/computed tomography(PET/CT)in patients with coronary heart disease(CHD).Methods The clinical data of myocardial metabolism imaging in 160 patients with CHD admitted to Guangdong Provincial People’s Hospital from April 16,2018 to April 2,2021 were retrospectively analyzed,and the image quality of the old and new glucose-regulating schemes and the adverse reactions of the two schemes were compared.Results(1)Among 38 cases of the old schemes had diabetes mellitus(DM)or abnormal glucose tolerance of patients(A1),29 patients had good image quality and 9 patients had poor image quality,among which 8 patients could be diagnosed by delayed image for 1h.29 cases of the new scheme had DM or patients(B2)with abnormal glucose tolerance,23 patients had good image quality and 6 patients had poor image quality,all of which could be diagnosed by delaying images for 1 h.The proportion of good image quality in A1 scheme was 76.3%(29/38),and that in B1 scheme was 79.3%(23/29).There was no statistical significance between the two schemes(P>0.05).(2)In the old scheme without DM or abnormal glucose tolerance of patients(A2),the proportion of good image quality was 67.9%(38/56),while the new scheme without DM or abnormal glucose tolerance of patients B2,the proportion of good image quality was 86.5%(32/37),and all the images could be diagnosed.(3)There were 3 patients with hypoglycemia in the old scheme,and no patients with adverse reactions of hypoglycemia in the new scheme.There was no statistical significance in the incidence of adverse reactions between the two schemes(P>0.05).Conclusion In the^(18)F-FDG PET/CT myocardial metabolism imaging of CHD patients,it is feasible to adopt the new glucose-regulating regimen,and the image quality is no different from the old schemes,and no adverse reactions such as hypoglycemia appear.
作者
向泽银
王淑侠
徐卫平
张晓春
周永荣
XIANG Ze-yin;WANG Shu-xia;XU Wei-ping;ZHANG Xiao-chun;ZHOU Yong-rong(Guangdong Academy of Medical Sciences,Guangdong Provincial People's Hospital,Guangdong Guangzhou 510080)
出处
《深圳中西医结合杂志》
2022年第20期1-5,139,共6页
Shenzhen Journal of Integrated Traditional Chinese and Western Medicine
基金
国家自然科学基金面上项目(81871437)
关键词
冠心病
糖尿病
正电子发射型计算机断层扫描
氟代脱氧葡萄糖
心肌代谢显像
Coronary heart disease
Diabetes mellitus
Positron emission tomography
^(18)F-fluorodeoxyglucose
Myocardial metabolism imaging
