期刊文献+

火针为主治疗白癜风疗效与安全的Meta分析 被引量:2

Meta Analysis of Efficacy and Safety of Fire Acupuncture in the Treatment of Vitiligo
原文传递
导出
摘要 目的系统评价火针为主治疗白癜风的疗效与安全性。方法通过检索中国知网(CNKI)、万方数据库(WF)、重庆维普(VIP)和PubMed、Cochrane图书馆、荷兰医学文摘数据库(Embase)等,按主题词+自由词,检索火针为主治疗白癜风的随机对照试验,检索时限均为自建库至2019年9月。由两名研究人员分别对检索的文献进行筛选分析,使用Cochrane偏倚风险评估方法评价纳入文献的质量及偏倚风险,应用RevMan5.3.5软件对数据进行Meta分析。结果纳入随机对照试验17篇,共计1336例患者,试验组(667例),对照组(669例),其中13篇报告了试验的相关不良反应,3篇出现了病例脱落。对比其他外治法、口服中药法,火针为主治疗白癜风,更具有临床优势,差异具有统计学意义(OR=3.19,95%CI[2.28,4.48],Z=6.73,P<0.00001);在皮损色素积分改善方面更明显(WMD=-0.82,95%CI[-0.89,-0.75],Z=23.12,P<0.00001);白斑面积减少更有优势(WMD=-2.79,95%CI[-3.26,-2.31],Z=11.53,P<0.00001);复发率显著降低(OR=0.34,95%CI[0.12,0.97],Z=2.01,P=0.04)。结论火针为主治疗白癜风在总有效率、皮损色素积分改善、白斑面积减少及复发率方面优于西医及其他口服治疗方法,值得推广。但该研究结论后期仍需纳入大样本、高质量文献进一步验证。 Objective To evaluate the efficacy and safety of fire acupuncture in the treatment of vitiligo.Methods By searching CNKI,wanfang database(WF),Chongqing VIP database and PubMed Cochrane library Embase database.Press subject+free word,and search for a randomized controlled trial of fire needles as the primary treatment for vitiligo.The retrieval time limit is all from the self-built database to September 2019.The retrieved literature was screened and analyzed separately by two researchers,and Cochrane risk assessment method was used to evaluate the quality of the included literature and the risk of bias.RevMan5.3.5 software was used for Meta analysis of the data.Results Seventeen randomized controlled trials were included.A total of 1336 patients were enrolled in the experimental group(667 patients)and the control group(669 patients).Thirteen of them reported adverse reactions related to the trial,and three reported cases of shedding.Compared with other external treatment methods of oral Chinese medicine,fire acupuncture mainly for the treatment of vitiligo,more clinical advantages,the difference was statistically significant(OR=3.19,95%CI[2.28,4.48],Z=6.73,P<0.00001),in the skin damage pigment integral improvement is more obvious(WMD=-0.82,95%CI[-0.89,-0.75],Z=23.12,P<0.00001);White spot area reduction is more advantageous(WMD=-2.79,95%CI[-3.26,-2.31],Z=11.53,P<0.00001);The recurrence rate decreased significantly(OR=0.34,95%CI[0.12,0.97],Z=2.01,P=0.04);Conclusion Fire acupuncture is better than western medicine and other oral treatment methods in the treatment of vitiligo,which is worthy of promotion.However,the conclusion of this study still needs to be further verified by incorporating a large sample of high-quality literatures.
作者 杨雪圆 闫小宁 蔡宛灵 贺冬 刘尧文 YANG Xue-yuan;YAN Xiao-ning;CAI Wan-ling;HE Dong;LIU Yao-wen(First Clinical Medical College of Shaanxi University of Traditional Chinese Medicine,Xianyang Shaanxi,712046 China;Hospital Dermatological Department of Shaanxi Province,Xi’an,710004 China;Danfeng County Hospital of TCM,Shangluo 726200 China;Changsha Medical University,Changsha,Hunan,410200 China)
出处 《时珍国医国药》 CAS CSCD 北大核心 2020年第10期2545-2550,共6页 Lishizhen Medicine and Materia Medica Research
基金 国家重点研发计划“中医药现代化研究重点专项”(2018YFC1705303) 陕西省重点研发计划重点项目(2018ZDXM-SF-010)
关键词 白癜风 火针 随机对照试验 META分析 系统评价 Vitiligo Fire needle Randomized controlled trials Meta-analysis Systematic review
  • 相关文献

参考文献25

二级参考文献129

共引文献219

同被引文献60

引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部