摘要
间充质干细胞(mesenchymal stem cells,MSCs)是一类中胚层起源的多能非造血成体干细胞,来源广泛,具有增殖分化、自我更新、免疫调节等能力,可同时参与先天性免疫和适应性免疫,可在多种炎症条件下诱导免疫耐受,其特有的低免疫原性及免疫调节作用近年来受到了广泛关注。间充质干细胞的免疫识别逃避及免疫应答抑制使其在银屑病的治疗中充满前景。该文就不同来源的间充质干细胞在银屑病治疗中的应用进展进行综述。
Mesenchymal stem cells(MSCs)are a kind of multipotent non hematopoietic adult stem cells originated from mesoderm,which have a wide range of sources,and the ability of proliferation and differentiation,self-renewal,immune regulation,etc.MSCs can participate in innate immunity and adaptive immunity at the same time,and can induce immune tolerance under a variety of inflammatory conditions.The unique low immunogenicity and immune regulation of MSCs have been noticed in recent years.The immune recognition escape and immune response inhibition of mesenchymal stem cells make them full of prospects in the treatment of psoriasis.This article reviews the application progress of mesenchymal stem cells from different sources in the treatment of psoriasis.
作者
贺思敏
丛宪玲
HE Si-min;CONG Xian-ling(Department of Dermatology,China-japan Union Hospital of Jilin University,Changchun 130000,China)
出处
《实用皮肤病学杂志》
2023年第3期168-173,179,共7页
Journal of Practical Dermatology
基金
吉林省科技发展计划项目(20210204150YY,20200601010JC)
关键词
银屑病
寻常性
干细胞
间充质
治疗
Psoriasis,vulgaris
Stem cells,mesenchymal
Treatment
