摘要
目的评价5种肾小球滤过率(GFR)评估方程在2型糖尿病人群(T2DM)中的优劣性。方法选取2015年12月至2017年2月在南昌大学第二附属医院行肾动态显像+肾小球滤过率检查的T2DM患者343例,以(99m)Tc-DTPA肾动态显像测定的GFR为参考标准,采用线性相关分析、Bland-Altman曲线分析、受试者工作特征(ROC)曲线等方法评估CKD-EPIScr方程、EPI-Asian方程、C-G方程、简化MDRD方程及简化MDRD中国人方程5种方程估测GFR(eGFR)与金标准组的一致性。结果Bland-Altman分析显示,CKD-EPIScr方程计算eGFR值与金标准组的一致性较好。5种方程得出的eGFR与GFR相关系数分别为0.894,0.894,0.872,0.890,0.886;ROC曲线面积依次分别为0.962,0.961,0.959,0.958,0.958(P>0.05)。结论CKD-EPIScr公式与金标准组的相关系数最高,ROC曲线下面积最大。在T2DM人群中,CKD-EPIScr方程可能更适合评估T2DM患者的eGFR。
Objective To study the advantage and disadvantage of the five estimated glomerular filtration rate equations in type 2 diabetes mellitus(T2 DM).Methods A retrospective analysis was made in 343 patients with T2DM who had underwent renal dynamic imaging and glomerular filtration rate examination in the Second Affiliated Hospital of Nanchang University from December 2015 to February 2017.The GFR was obtained by(99m)Tc-DTPA renal dynamic imaging and was used as a reference standard,the consistency of five equations(CKD-EPIScr equation,EPI-Asian equation,CG equation,simplified MDRD equation and simplified MDRD Chinese equation)with gold standard group was evaluated by linear correlation,Bland-Altman analysis,receiver operating characteristic(ROC)curve and so on.Results BIand-Altman analysis showed that the eGFR calculated by CKD-EPIScr equation was in good agreement with the gold standard group.The correlation ocefficient of eGFR and GFR obtained by the five equations was 0.894,0.894,0.872,0.890 and 0.886,respectively.The area under the ROC curve(AUC)was 0.962,0.961,0.959,0.958 and 0.958,respectively(P>0.05).Conclusion The CKD-EPIScr equation has the highest correlation coefficient with the gold standard group and the largest area under the ROC curve.Therefore,CKD-EPIScr equation may be more suitable for evaluating eGFR in patients with T2 DM.
作者
胡丹
樊友文
涂卫平
HU Dan;FAN Youwen;TU Wei-ping(Department of Endocrinology,the Seventh Affiliated Hospital of Sun Yat-sen University,Shenzhen 518107,China;不详)
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2020年第9期744-748,共5页
Chinese Journal of Practical Internal Medicine
关键词
2型糖尿病
肾小球滤过率
估测肾小球滤过率
肾小球滤过率评估方程
type 2 diabetes mellitus
glomerular filtration rate
estimated glomerular filtration rate
estimated glomerular filtration rate equation
