摘要
目的:探讨胃蛋白酶原(PG)水平与及幽门螺旋杆菌(Hp)感染及胃黏膜疾病的关系。方法:选取2016-09—2018-09有消化道症状且经胃镜诊断为慢性胃病的316例患者作为研究对象,根据患者病情分为浅表性胃炎76例,消化性溃疡98例,慢性萎缩性胃炎81例,胃癌61例。另选取同期健康体检者90例为健康组。采用化学发光法检测5组血清中胃蛋白酶原Ⅰ(PGⅠ)和胃蛋白酶原Ⅱ(PGⅡ)及两者比值(PGR),采用13C尿素呼气试验和胶乳免疫法检测5组Hp感染状态;采用Spearman相关性分析PGⅠ、PGⅡ、PGR与Hp感染的相关性,分别采用ROC曲线评价PGⅠ、PGⅡ、PGR、Hp对胃黏膜病变的诊断价值,采用Logistic回归分析影响胃黏膜病变的独立危险因素。结果:随着胃黏膜病变的加重,PGⅠ和PGR水平下降,各组间差异有统计学意义(P<0.05);Hp阴性患者的PGⅠ、PGⅡ和PGR显著高于Hp阳性患者,差异有统计学意义(P<0.05);Spearman相关性分析表明,Hp感染与PGⅠ、PGⅡ、PGR呈负相关性,胃黏膜病变与PGⅠ、PGⅡ、PGR呈负相关性(P<0.05);Logistic回归分析结果表明PGⅠ<72、PGR<3、Hp阳性是影响胃黏膜病变的独立危险因素;PGⅠ、PGⅡ、Hp、PGR的ROC曲线下面积(AUC)分别为0.545、0.726、0.738、0.806。结论:PGⅠ<72、PGR<3、Hp阳性有助于胃黏膜病变的病情诊断,Hp阴性胃黏膜病变患者PGⅠ、PGⅡ和PGR显著高于Hp阳性患者。
Objective:To analyze the relationship between pepsinogen level and Hp infection and the diagnosis of different gastric mucosal diseases.Method:A total of 316 patients with gastrointestinal symptoms diagnosed as chronic gastropathy by gastroscopy who admitted to the gastroenterology clinic or inpatient department of our hospital from September 2016 to September 2018 were selected as research objects.According to their conditions,the patients were divided into 76 cases of superficial gastritis,98 cases of peptic ulcer,81 cases of chronic atrophic gastritis and 61 cases of gastric cancer group.In addition,90 patients who underwent physical examination during the same period were selected as the healthy group.The serum levels of PGⅠ,PGⅡ,and PGR were tested by chemical luminescence method,the Hp infection status was tested by 13C urea breath test and latex immunoturbidimetry method.Spearman correlation analysis was adopted to analyze the correlation between PGⅠ,PGⅡ,PGR and Hp infection.The values of PGⅠ,PGⅡ,Hp,PGR to the diagnosis of gastric cancer were evaluated by ROC curve.Independent risk factors of gastric mucosal lesions were analyzed by Logistic regression analysis.Result:With the aggravation of gastric mucosal lesions,PGⅠand PGR levels decreased,and the difference between the groups was statistically significant(P<0.05).The PGⅠ,PGⅡand PGR of patients with negative Hp were significantly higher than those of patients with positive Hp,with statistically significant differences(P<0.05).Spearman correlation analysis showed that Hp infection was negatively correlated with PGⅠ,PGⅡand PGR,and gastric mucosal lesions were negatively correlated with PGⅠ,PGⅡand PGR(P<0.05).The results of Logistic regression analysis showed that PGⅠ<72,PGR<3 and positive Hp were independent risk factors affecting gastric mucosal lesions.The area under the ROC curve(AUC)of PGⅠ,PGⅡ,Hp and PGR were 0.545,0.726,0.738 and 0.806,respectively.Conclusion:PGⅠ<72,PGR<3 and positive Hp might be helpful for the diagnosis of gastric mucosal diseases,and patients with negative Hp gastric mucosal diseases had significantly higher levels of PGⅠ,PGⅡand PGR than patients with positive Hp.
作者
葛海燕
陈桂明
GE Haiyan;CHEN Guiming(Department of Clinical Laboratory,Gaoyou People's Hospital,Gaoyou,225600,China)
出处
《临床血液学杂志（输血与检验）》
CAS
2020年第1期97-100,共4页
Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)
关键词
胃蛋白酶原
幽门螺杆菌
胃黏膜疾病
诊断
pepsinogen
helicobacter pylori
gastric mucosal lesions
diagnosis
