摘要
肺癌又称原发性支气管癌,是起源于支气管黏膜或腺体的最常见的肺部原发性恶性肿瘤。依据组织病理类型,肺癌可分为小细胞癌(SCLC)和非小细胞癌(NSCLC)。NSCLC约占肺癌的85%,其发病机制目前尚不清楚。本研究就长链非编码RNA(lncRNA)X染色体失活特异转录本(XIST)参与NSCLC进展可能的机制进行综述,以期对深入研究NSCLC发生发展的机制提供新的思路。2016-01-01-2020-12-31检索PubMed、万方和中国知网数据库相关文献,纳入标准:lncRNA XIST参与NSCLC进展相关文献。排除标准:综述类文献;不同期刊重复发表文献。最终纳入38篇文献进行分析。lncRNA XIST是早期发现的lncRNAs之一,可调控机体多种生理病理学过程。目前,越来越多的研究结果表明,lncRNA XIST与NSCLC细胞的增殖、凋亡、上皮间质转化、表观遗传和耐药密切相关。lncRNA XIST诱导产生的miR-140依赖性的p53凋亡抑制蛋白(iASPP)可促进肿瘤的生长和耐药;而下调lncRNA XIST可促进活性氧(ROS)产生和核苷酸结合寡聚结构域含亮氨酸重复序列和含Pyrin结构域3(NLRP3)炎性小体激活,进而引起细胞焦亡;此外,lncRNA XIST可以增加RING1表达并增强Wnt/β-catenin信号通路表达促进NSCLC细胞分裂、转移和侵袭;lncRNA XIST还可通过表观遗传机制抑制Kruppel样因子2(KLF2)表达促进癌细胞增殖、迁移和侵袭;有趣的是,下调lncRNA XIST后可抑制多耐药基因(MDR1)和多耐药相关蛋白(MRP1)表达进而影响细胞耐药。因此,探索lncRNA XIST对肺癌发生发展的作用机制对NSCLC进入分子靶向治疗的新时代具有重要意义。
Lung cancer or primary bronchogenic carcinoma was the most common primary malignant tumor of the lung,originating from bronchial mucosa or glands.According to histopathological type,it could be divided into small cell lung carcinoma(SCLC)and non-small cell lung carcinoma(NSCLC).Approximate 85%of the lung cancer cases were NSCLC.However,the underlying mechanism was still unclear,thus this review summarized the potential mechanism of long non-coding RNA(lncRNA)X-inactive specific transcript(XIST)in the progress of NSCLC,in order to provide new strategy for further understanding the mechanism of NSCLC.Retrieved relevant documents from the PubMed,Wanfang and China National Knowledge Base from 2016-01-01 to 2020-12-31.Inclusion criteria:related literatures on the progress of lncRNA XIST regulation of NSCLC.Exclusion criteria:review literature;different journals repeatedly articles.Finally,38 articles were include for analysis.lncRNA XIST is one of the early discovered lncRNAs,which can regulate a variety of physiological and pathological processes in the body.So far,increasing number of scientific research has shown that lncRNA XIST is closely related to the cell proliferation,apoptosis,Epithelial-mesenchymal transition,epigenetics and chemoresistance of NSCLC.It’s miR-140-dependent inhibitory member of the apoptosis-stimulating protein of p53(iASPP)induced by lncRNA XIST that can promote growth and drug resistance of tumor.However,down-regulation of lncRNA XIST can promote the production of reactive oxygen species(ROS)and the activation of Nucleotide-binding oligomerization domain leucine-rich repeat and pyrin domain containing protein 3(NLRP3)inflammasomes and it is leading to pyroptosis.In addition,lncRNA XIST can increase the expression of RING1 and enhance the expression of Wnt/β-catenin signaling pathway to promote NSCLC cell division,metastasis and invasion.lncRNA XIST can also inhibit the expression of kruppel-like factor 2(KLF2)through epigenetics mechanisms to accelerate the proliferation,migration and invasion of cancer cell.Interestingly,cell resistance can be affected by inhibiting multidrug resistance gene1(MDR1)and multidrug resistance protein1(MRP1)due to down-regulation lncRNA XIST.Therefore,it’s of significance to further explore the mechanism of occurrence and development of lung cancer caused by lncRNA XIST so as for better treatment of NSCLC with molecular targeted therapy.
作者
宁鲁
王丽娜
张子腾
NING Lu;WANG Li-na;ZHANG Zi-teng(Clinical Medicine Department,Jining Medical University,Jining272000,China;Affiliated Hospital of Jining Medical University,Jining272000,China)
出处
《社区医学杂志》
CAS
2021年第19期1203-1208,共6页
Journal Of Community Medicine
基金
国家自然科学基金青年基金(81802290,81800182)
山东省自然科学基金(ZR2018BH020)
关键词
非小细胞肺癌
长链非编码RNA
X染色体失活特异转录本
细胞增殖
细胞凋亡
上皮间质转化
non-small cell lung carcinoma
long non-coding RNA
X-inactive specific transcript
cell proliferation
cell apoptosis
epithelial-mesenchymal transition
