摘要
目的本研究分析逍遥散加味颗粒治疗早期桥本甲状腺炎(HT)的临床疗效,旨在为临床治疗提供依据。方法选取2018-03-01-2020-01-31辽宁中医药大学附属第三医院收治的80例HT患者作为研究对象,根据组间基本特征均衡可比的原则,分为观察组和对照组,每组各40例。对照组采用安慰剂治疗,随诊观察,观察组采用逍遥散加味颗粒治疗。比较两组患者治疗后的临床疗效;治疗前后促甲状腺激素(TSH)、血清游离三碘甲腺原氨酸(FT3)和血清游离甲状腺素(FT4)水平;治疗前后患者甲状腺过氧化物酶抗体(TPOAb)和抗甲状腺球蛋白抗体(TGAb)水平变化等情况。结果治疗后,对照组总有效率为12.5%,低于观察组的97.5%,χ2=60.87,P<0.05。治疗后,观察组TSH、FT3和FT4水平与对照组比较,差异无统计学意义,均P>0.05。治疗后,观察组TPOAb水平为(74.5±7.51)IU/mL,低于对照组的(696.2±35.80)IU/mL,t=110.00,P<0.001;TGAb水平为(101.3±7.84)IU/mL,低于对照组的(610.4±32.80)IU/mL,t=95.47,P<0.001。结论逍遥散加味颗粒治疗早期HT具有显著临床疗效,可延缓病情发展。
Objective This study analyzed the clinical efficacy of Xiaoyaosan Jiawei Granule in the treatment of early Hashimoto’s thyroiditis(HT),aimed to provide reference for the treatment.Methods A total of eighty patients with Hashimoto’s thyroiditis admitted in Third Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from March 1 to January 31,2018 were selected as the research objects.According to the principle of balanced and comparable basic characteristics between the groups,they were divided into an observation group and a control group,each group had 40 examples.The control group was treated with placebo,followed by observation,and the observation group was treated with Xiaoyaosan Jiawei granules.Compared the clinical efficacy after treatment,thyroid stimulating hormone(TSH),serum free triiodothyronine(FT3),serum free thyroxine(FT4),thyroid peroxidase antibody(TPOAb)and anti-thyroglobulin antibody(TGAb)level changes in patients before and after treatment.Results After treatment,the total effective rate of the control group was 12.5%,which was lower than 97.5%of the observation group,χ2=60.87,P<0.05.After treatment,the levels of TSH,FT3 and FT4 in the observation group were not significantly different from those in the control group,all P>0.05.After treatment,the TPOAb level in the observation group was(74.5±7.51)IU/ml,which was lower than that in the control group(696.2±35.8)IU/ml,t=110.00,P<0.001.TGAb level was(101.3±7.84)IU/ml,which was lower than the control group’s(610.4±32.80)IU/ml,t=95.47,P<0.001.Conclusion Xiaoyaosan Jiawei Granules has a significant clinical effect on early Hashimoto’s thyroiditis and delays the development of the disease.
作者
李蕊
董佳妮
LI Rui;DONG Jia-ni(Third Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110005,China)
出处
《社区医学杂志》
CAS
2021年第2期109-112,共4页
Journal Of Community Medicine
