摘要
目的炎性因子水平上升是脑梗死早期病理变化,可严重损伤脑动脉和全身血管的内皮功能,而神经功能的损伤程度直接影响预后,因此在溶栓同时控制炎症因子水平、减少神经功能损伤非常重要。本研究分析丁苯酞联合阿替普酶溶栓对脑梗死患者神经功能及炎性因子水平影响。方法选择2017-06-08—2018-12-11本院收治的84例脑梗死患者为研究对象,根据组间基本特征均衡可比的原则分为观察组和对照组,每组42例。对照组采用阿替普酶溶栓治疗,观察组采用丁苯酞联合阿替普酶溶栓治疗。对比分析两组患者白细胞介素-6(interleukin-6,IL-6)、IL-10、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、C反应蛋白(C reactive protein,CRP)水平。结果治疗后观察组美国国立卫生研究院卒中量表(National Institute of Health Stroke Scale,NIHSS)评分为(4.89±1.74)分,低于对照组的(6.14±1.98)分,t=3.073,P=0.003;IL-6水平为(12.09±1.24)ng/L,低于对照组的(15.33±2.18)ng/L,t=8.372,P<0.001;IL-10水平为(8.51±1.12)ng/L,低于对照组的(10.95±2.71)ng/L,t=5.393,P<0.001;TNF-α水平为(9.38±1.56)ng/L,低于对照组的(11.94±2.33)ng/L,t=5.917,P<0.001;CRP水平为(8.84±1.37)mg/L,低于对照组的(11.16±2.08)mg/L,t=6.037,P<0.001。结论对脑梗死患者施行丁苯酞联合阿替普酶溶栓治疗,可有效减少患者神经功能损伤,并降低炎症因子水平。
OBJECTIVE Rising inflammatory factor levels are early pathological changes of cerebral infarction,which can seriously damage the endothelial function of cerebral arteries and systemic blood vessels,and the degree of neurological damage directly affects prognosis.Therefore,it is very important to control inflammatory factor levels and reduce neurological damage during thrombolysis.This study analyzed the effects of butylphthalide combined with alteplase thrombolysis on neurological function and inflammatory factor levels in patients with cerebral infarction.METHODS A total of84 patients with cerebral infarction admitted to our hospital from June 8,2017 to December 11,2018 were selected as the research subjects.According to the principle of balanced and comparable basic characteristics between groups,they were divided into observation group and control group,with 42 cases in each group.The control group was treated with alteplase and the observation group was treated with butylphthalide combined with alteplase.Levels of interleukin-6(IL-6),IL-10,tumor necrosis factor-α(TNF-α)and c reactive protein(CRP)were compared between the two groups.RESULTS The National Institute of Health Stroke Scale(NIHSS)score of the observation group after treatment was(4.89±1.74)points,which was lower than the control group(6.14±1.98)points,t=3.073,P=0.003.IL-6 level was(12.09±1.24)ng/L,lower than(15.33±2.18)ng/L of the control group,t=8.372,P<0.001.IL-10 level was(8.51±1.12)ng/L,lower than(10.95±2.71)ng/L in the control group,t=5.393,P<0.001.TNF-αlevel was(9.38±1.56)ng/L,lower than(11.94±2.33)ng/L in the control group,t=5.917,P<0.001.CRP level was(8.84±1.37)mg/L,which was lower than that of the control group(11.16±2.08)mg/L,t=6.037,P<0.001.CONCLUSION Treatment of patients with cerebral infarction with butylphthalide combined with alteplase thrombolytic therapy can effectively reduce neurological damage and reduce inflammatory factor levels.
作者
窦晓丽
杨珂
DOU Xiao-li;YANG Ke(Department of Neurology,Henan Hongli Hospital,Xinxiang453400,P.R.China)
出处
《社区医学杂志》
2020年第5期324-327,共4页
Journal Of Community Medicine
关键词
丁苯酞
阿替普酶溶栓
脑梗死
神经功能
炎性因子
butylphthalide
alteplase thrombolysis
cerebral infarction
neural function
inflammatory factors
