摘要
目的老年2型糖尿病患者易并发多种并发症,严重威胁患者生命安全,有效的并发症监测指标有助于指导临床采取针对性预防措施。本研究分析老年2型糖尿病及其并发症患者发生情况与糖化血红蛋白(glycated-hemoglobin,HbA1c)的相关性,判断HbA1c在预防老年2型糖尿病患者及其并发症中的价值。方法选取2018-01-01-2018-12-31广饶县大码头中心卫生院收治的138例老年糖尿病患者作为病例组,其中43例合并有并发症,95例无并发症;另选取本院同期接收的138名无糖耐量异常老年健康体检者作为对照组。观察比较对照组和病例组空腹血糖(fast plasma glucose,FPG)和HbA1c水平,分析老年2型糖尿病及并发症与HbA1c相关性。结果病例组138例患者中43例合并有并发症,其中糖尿病肾病12例,视网膜病变17例,神经系统病变7例,心脑血管疾病5例,其他2例;病例组FPG水平为(9.77±2.58)mmol/L,高于对照组的(5.12±1.65)mmol/L,t=17.837,P<0.001;病例组HbA1c水平为(9.38±2.24)%,高于对照组的(5.47±1.69)%,t=16.369,P<0.001。病例组合并并发症患者FPG水平为(11.32±3.03)mmol/L,高于无并发症患者的(9.23±2.91)mmol/L,t=3.858,P<0.001;病例组合并并发症患者HbA1c水平为(12.01±2.83)%,高于无并发症患者的(7.54±1.76)%,t=9.555,P<0.001。老年2型糖尿病及并发症与HbA1c水平密切相关,HbA1c水平越高,老年2型糖尿病(OR=60.800,95%CI为23.195~159.374,P<0.001)及并发症(OR=14.909,95%CI为3.405~65.272,P<0.001)发生率越高。结论老年2型糖尿病及并发症患者FPG和HbA1c水平高于健康人群,合并并发症患者FPG和HbA1c水平高于无并发症患者,HbA1c水平越高,老年2型糖尿病及其并发症发生率越高。
OBJECTIVE Elderly patients with type 2 diabetes are prone to multiple complications,which seriously threaten the life of patients.Effective complication monitoring indicators are helpful to guide the clinical adoption of targeted preventive measures.This study analyzed the correlation between glycinated-hemoglobin(HbA1c)and type 2 diabetes mellitus and its complications in the elderly,and determined the value of HbA1c in the prevention of complications in elderly patients with type 2 diabetes mellitus.METHODS From January 1 to December 31,2018,138 elderly diabetic patients in Guangrao County DaMaTou Central Health Center were selected as the case group,of which 43 had complications and 95 had no complications.In addition,138 healthy elderly patients with abnormal glucose tolerance received in our hospital during the same period were selected as the control group.Fast plasma glucose(FPG)and HbA1c levels in the control group and the case group were compared,and the correlation between HbA1c and type 2 diabetes mellitus and its complications in the elderly was analyzed.RESULTS Among the 138 patients in the case group,43 had complications,including 12 cases of diabetic nephropathy,17 cases of retinopathy,7 cases of neurological diseases,5 cases of cardiovascular and cerebrovascular diseases,and the other 2 cases.FPG level in the case group was(9.77±2.58)mmol/L,higher than that in the control group(5.12±1.65)mmol/L(t=17.837,P<0.001).The HbA1c level in the case group was(9.38±2.24)%,higher than that in the control group(5.47±1.69)%(t=16.369,P<0.001).The FPG level of patients with combined complications was(11.32±3.03)mmol/L,higher than that of patients without complications(9.23±2.91)mmol/L(t=3.858,P<0.001).HbA1c level was(12.01±2.83)%in patients with combined complications,higher than that in patients without complications(7.54±1.76)%(t=9.555,P<0.001).Type 2 diabetes in the elderly and its complications were closely related to HbA1c level.The higher the HbA1c level,the higher the incidence of type 2 diabetes in the elderly(OR=60.800,95%CI was 23.195-159.374,P<0.001)and its complications(OR=14.909,95%CI was 3.405-65.272,P<0.001).CONCLUSIONS The levels of FPG and HbA1c in elderly patients with type 2 diabetes and complications are higher than those in healthy people,and FPG and HbA1c levels in patients with complications are higher than those in patients without complications.The higher HbA1c levels were,the higher the incidence of type 2 diabetes and complications is in elderly patients.
作者
王国丽
贾素花
WANG Guo-Li;JIA Su-hua(Internal Medicine,Guangrao County DaMaTou Central Health Center,Guangrao 257337,P.R.China)
出处
《社区医学杂志》
2019年第24期1590-1592,1596,共4页
Journal Of Community Medicine
关键词
老年人
2型糖尿病
并发症
糖化血红蛋白
空腹血糖
elderly
type 2diabetes
complications
glycated-hemoglobin
fast plasma glucose
