摘要
甲状腺相关眼病(Thyroid-associated ophthalmopathy,TAO)属于难治性疾病,其发病与辅助性T细胞17(T-helper 17 lymphocyte,Th17)/调节性T细胞(Regulatory cell,Treg)细胞免疫失衡有关。“肝开窍于目”是中医学对肝病及眼、眼病及肝的理论学说的系统总结,可指导中医对TAO的临床诊疗。研究表明从“肝开窍于目”论治TAO可在一定程度上调节Th17/Treg细胞免疫失衡,达到防治疾病的目的。本文从Th17/Treg失衡促进TAO的发生发展、“肝开窍于目”理论在TAO病因病机中的作用、“肝开窍于目”生理和Th17/Treg免疫平衡的契合性等方面探讨Th17/Treg细胞免疫失衡在TAO中的作用,以期揭示中医药通过调控Th17/Treg失衡防治TAO的科学内涵。
Thyroid associated ophthalmopathy(TAO)is a refractory disease,which is related to Th17/Treg cellular immune imbalance."liver opens at the eyes"is a systematic summary of the theories of liver disease affecting the eye and eye disease affecting the liver in traditional Chinese medicine,which can guide the clinical diagnosis and treatment of TAO in traditional Chinese medicine.Studies have shown that the treatment of TAO from the perspective of"liver opens at the eyes"can regulate the immune imbalance of Th17/Treg cells to a certain extent,so as to achieve the purpose of disease prevention and treatment.This paper discusses the role of Th17/Treg cellular immune imbalance in TAO,from the aspects of Th17/Treg imbalance promoting the occurrence and development of TAO,the role of"liver opens at the eyes"theory in the etiology and pathogenesis of TAO,and the consistency between"liver opens at the eyes"physiology and Th17/Treg immune balance.In order to reveal the scientific connotation of traditional Chinese medicine in preventing and treating TAO by regulating Th17/Treg imbalance.
作者
王萍
符宇
段飞
颜焱
王书玓
王颖
燕树勋
Wang Ping;Fu Yu;Duan Fei;Yan Yan;Wang Shudi;Wang Ying;Yan Shuxun(The First Affiliated Hospital of Henan University of CM,Zhengzhou 450000,China;Hubei Chen’s Gall Disease Academic School Inheritance Studio of the State Administration of Traditional Chinese Medicine Henan Workstation,Zhengzhou 450000,China;The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2023年第10期3394-3400,共7页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
河南省卫生健康委员会河南省第二批中医药拔尖人才培养项目(CZ0237-02),负责人:燕树勋
