摘要
目的系统评价红参改善代谢综合征作用,为临床实践提供依据。方法分别对英文数据库PubMed、Embase、The Cochrane Library、Web of Science、ClinicalTrials.gov以及中文数据库万方和中国知网进行全面检索,检索时限从建库至2022年5月,查询关于红参辅助治疗代谢综合征的临床随机对照试验。依据纳入排除标准筛选文献并对其进行质量评估,随后通过RevMan 5.4.1软件对纳入研究进行Meta分析。结果共纳入17个随机对照试验,共包含957例患者,其中红参实验组共482例、安慰剂对照组共475例。与对照组比较,受试者服用红参后能显著改善空腹血糖、总胆固醇、低密度脂蛋白、收缩压及舒张压水平(P<0.05),其作用效果与所患疾病、年龄、给药时长、给药剂量有关。结论本文研究发现红参在治疗代谢综合征方面具有良好的疗效,为红参临床治疗代谢综合征提供了循证依据。
Objective To systematically evaluate the effect of red ginseng on improving metabolic syndrome,and to provide basis for clinical practice.Methods Retrieval from PubMed,Embase,The Cochrane Library,Web of Science,Clinical Trials Gov,WanFang Data and CNKI databases,articles of RCTs about red ginseng on improving metabolic syndrome were included.The searching range was from the establishment of the database to May 2022.The articles were screened according to inclusion and exclusion criteria,and then the inclusion study was analyzed through RevMan 5.4.1 software.Results Totally 17 randomized controlled trials involving 957 patients were included.Compared with the control group,red ginseng exhibited significant effect on fasting blood glucose,total cholesterol,low-density lipoprotein,systolic blood pressure and diastolic blood pressure(P<0.05),and its effect was related to the disease,age,duration of administration and dosage.Conclusion Red ginseng could significantly improve the symptoms of hyperglycemia,hyperlipidemia and hypertension in metabolic syndrome,which provides a theoretical basis for clinical use of red ginseng in treating metabolic syndrome.
作者
陈偲敏
张颖凌
许玉
徐宏喜
Chen Simin;Zhang Yingling;Xu Yu;Xu Hongxi(School of Pharmacy,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2023年第9期3182-3192,共11页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
关键词
红参
代谢综合征
血糖
血压
血脂
META分析
Red ginseng
Metabolic syndrome
Blood glucose
Blood pressure
Blood lipid
Meta-analysis
