摘要
白发症指人类个体因头发毛干中色素减退或缺失使得头发变白或变灰的生理与病理现象,黑素细胞干细胞(MeSCs)向头发中毛母质提供分泌色素的黑素细胞以促进毛干着色,且其生理活动易受情志刺激影响,故MeSCs功能稳态的维持与头发色素盈亏密切相关。藏象理论是中医学体现整体医学思维的重要组成部分,《内经》有云:肝藏血,发为血之余,肾藏精,其华在发,该二脏既与头发的生理病理表现密切相关,其生理功能又易受情志刺激影响,故从中医肝肾藏象理论的视角探讨情志刺激影响MeSCs稳态变化从而诱发白发症的相关机制,可为中西医结合治疗白发症提供新思路。
Poliosis refers to the physiological or pathological phenomenon that human individual hair becomes white or grayed out due to the hypopigmentation or deficiency in the hair shaft.melanocyte stem cells(MeSCs)provide pigmentsecreting melanocytes(MC)to the hair stroma to promote the coloration of the hair shaft.The maintenance of steady state is closely related to the profit and loss of hair pigment.Emotional stimulation is one of the causes that induce pathological poliosis by destroying the steady state.According to the visceral manifestation theory of traditional Chinese medicine,the liver stores blood,and the kidney stores essence in addition to blood in hair,which is also rich in hair.These two zang organs are vulnerable to emotional stimulation.Therefore,the related mechanism of emotional stimulation affecting the steady-state changes of MeSCs and inducing poliosis was explored based on the liver and kidney visceral manifestation theory of traditional Chinese medicine,which would provide new ideas for the treatment of poliosis by the combination of traditional Chinese medicine and western medicine.
作者
牟翔宇
高冬梅
郭英慧
王杰琼
高明周
王常瞵
张守亮
乔明琦
Mu Xiangyu;Gao Dongmei;Guo Yinghui;Wang Jieqiong;Gao Mingzhou;Wang Changlin;Zhang Shouliang;Qiao Mingqi(College of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;College of Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;College of Innovative Research Institute of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Jinan Qingzhenmei Traditional Chinese Medicine Technology Co.,Ltd,Jinan,250355)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2023年第4期1488-1493,共6页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家科学技术部国家重大新药创制专项(SQ2017ZX090301064):中药新药丹皮酚滴丸、柴芍皂苷软胶囊和贞芍醇甘胶囊的研发与其关键创新技术,负责人:武继彪
国家自然科学基金委员会面上项目(82074293):由β-arrestin/KCTD介导的GABAR/cAMP/PKA失敏信号途径在PMDD肝气逆证海马应激损伤发生及中药干预机制研究,负责人:郭英慧
济南市科学技术局济南市“高校20条”资助项目(2020GXRC002):情志刺激甲状腺、乳腺结节病变的个性化差异与其个性化有效防治,负责人:乔明琦
关键词
肝藏象
肾藏象
情志刺激
白发症
黑素细胞干细胞
Liver visceral manifestation
kidney visceral manifestation
Poliosis
Emotional stimulation
Melanocyte stem cells(MeSCs)
