摘要
肠易激综合征(Irritable bowel syndrome,IBS)是一种功能性肠病,以间歇性腹痛伴或不伴有排便习惯改变、腹胀为主要临床特征。IBS的发病机制复杂,缺乏有效的治疗药物,目前的研究表明,可能与内脏高敏、肠动力异常、黏膜屏障破坏、肠道免疫失调、慢性低度炎症、脑肠互动异常等有关。现有研究表明肥大细胞(Mast cells,MCs)参与IBS发病的多个环节,并扮演重要角色,其分泌的组胺、类胰蛋白酶、细胞因子等介质影响IBS的发生与发展;靶向肥大细胞的药物研究已经取得初步进展,中医药调控IBS的机制与肥大细胞密切相关,本文主要对肥大细胞在IBS发病中的机制进行综述,并结合肥大细胞在中医药治疗IBS的研究现状,以期为中医药治疗该病提供新的科学依据和治疗思路。
Irritable bowel syndrome(IBS)is a functional bowel disease characterized by abdominal pain,abdominal discomfort and changes in bowel habits.Its pathogenesis is uncertain and lack of effective therapeutic drugs.Current research shows that it may be related to visceral hypersensitivity,abnormal intestinal motility,mucosal barrier destruction,intestinal immune disorders,chronic low-grade inflammation,and abnormal brain-intestinal interaction.Increasing evidence suggests that mast cells(MCs)play an important role in the pathogenesis of IBS.The secreted histamine,tryptase,cytokine and other mediators from MCs affect the occurrence and development of IBS in multiple links.Preliminary progress has been made in drug research targeting mast cells.The mechanism of Traditional Chinese medicine(TCM)drugs regulating IBS is closely related to mast cells.This article mainly reviews the relationship between mast cells and IBS and the analysis of the intervention mechanism of mast cells in TCM.
作者
王楷
宋玮
侯雨君
陈颖
廖晨希
谭玉
周思远
Wang Kai;Song Wei;Hou Yujun;Chen Ying;Liao Chenxi;Tan Yu;Zhou Siyuan(Chengdu University of Traditional Chinese Medicine,College of Acupuncture and Massage,Chengdu 610075,China;Chengdu University of Traditional Chinese Medicine,College of Basic Medicine,Chengdu 610075,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2023年第2期605-611,共7页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家自然科学基金委员会面上项目(82074558):培土抑木针法通过肥大细胞源性外泌体miRNA途径重塑IBS-D肠粘膜屏障的机制研究,负责人:周思远
关键词
肥大细胞
肠易激综合征
机制
中医药
Mast cells
Irritable bowel syndrome
Pathogenesis
Traditional Chinese medicine
