摘要
目的基于动物实验模型,总结针刺治疗骨质疏松的研究现状及进展。方法采用计算机检索近5年中国知网(CNKI)、维普数据库(VIP)、万方数据库(WanFang Data)、中国生物医学文献数据库(CBM)以及PubMed、EMbase、The Cochrane Library等数据库中有关针刺治疗骨质疏松动物模型的研究资料进行评价分析。结果总结15项实验研究,发现针刺防治骨质疏松的作用机制主要体现在调节成骨和破骨相关的OPG/RANK/RANKL、Wnt/β-catenin、MAPKs信号传导通路,调节肠道钙吸收,上调成骨相关蛋白BMP-2、RUNX2的表达,提高雌激素水平,抑制瘦素释放,调整胰岛功能及协调组蛋白修饰等方面。结论近5年来,针刺治疗骨质疏松的作用机制研究更加深入,在影响表观遗传、中枢调控和调节肠道物质吸收等方面有新发现。
Objective To review the therapeutic mechanism of acupuncture for osteoporosis on animal models.Methods Databases including PubMed,EMBASE,Cochrane Library,Chinese Biomedical database(CBM),Chinese National Knowledge Infrastructure(CNKI),Chinese Science and Technology Periodical database(VIP)and WanFang database were searched to collect experimental studies on acupuncture for osteoporosis from Jan.1st,2016 to Apr.11th,2021.Results According to 15 selected experimental studies,we found that the mechanism of acupuncture for osteoporosis including modulating bone metabolism related signaling transductions through OPG/RANK/RANKL,Wnt/β-catenin and MAPKs pathways,promoting the absorption of intestinal calcium,enhancing the expression of osteoblast related protein BMP-2 and RUNX2,increasing the secretion of estrogen,suppressing the release of leptin,regulating the function of islet and gene modification.Conclusion In recent 5 years,the studies on the mechanism of acupuncture in the treatment of osteoporosis has been more prosperous,especially in the aspects of affecting epigenetics,central regulation and regulating intestinal material absorption,which updates the insights for the effectiveness of acupuncture on the treatment for osteoporosis.
作者
朱婵
张强
韩栩珂
姚承佼
陈秋
Zhu Chan;Zhang Qiang;Han Xuke;Yao Chengjiao;Chen Qiu(Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610072,China;Chengdu University of TCM,Chengdu 611130,China;Sichuan Provincial Orthopedic Hospital,Chengdu 610041,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2022年第7期2883-2891,共9页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
关键词
针刺
骨质疏松症
机制
动物模型
综述
Acupuncture
Osteoporosis
Mechanism
Animal model
Review
