摘要
目的系统评价卵巢癌患者中医证候分布规律。方法计算机检索中国知网、万方数据库、中文科技期刊全文数据库、中国生物医学文献数据库、Pubmed、Web of Science、The Cochrane Library,文献检索自建库截至2020年12月11日,合计收集文献6445篇,纳入有关卵巢癌中医证候的相关文献8篇,使用Excel对数据进行整理,卡方检验检测不同证候出现频次是否具有统计学意义,通过聚类分析将不同类型证候进行分类,运用SPSS软件对数据进行分析。结果本研究纳入8篇合格文献,包含765例卵巢癌患者,涉及18种中医证候。对18种中医证候出现频次进行两两比较的χ^(2)检验,结果显示脾肾亏虚证、血瘀证、阳虚证、痰湿凝聚证以及阴虚证是需重点研究的高频中医证候;将复合型中医证候拆分与原有单证型中医证候合并,得到13种单证型中医证候,对此进行聚类分析,结果显示共分为三大类,第一类:脾虚、血瘀;第二类:湿邪、阴虚、肾虚、气滞、气虚;第三类:痰凝、邪热、肝郁、阳虚、血虚、气郁。第一类单证显示频数最大。结论根据统计结果分析可知,卵巢癌中医证候中脾肾亏虚证、血瘀证、阳虚证、痰湿凝聚证以及阴虚证是需重点研究的高频中医证候,脾虚、血瘀二项单证在卵巢癌中医证候中的辨证分型具有较大的临床意义。
Objective To systematically review the distribution pattern of TCM syndromes in ovarian cancer patients.Methods A computer search of CNKI,Wanfang database,VIP,China Biology Medicine disc,PubMed,Web of Science,The Cochrane Library was conducted as of December 11,2020,and 6,445 papers were collected,including 8 papers related to TCM syndromes of ovarian cancer.The data were organized using Excel,and the chi-square test was used to detect whether the frequency of different symptoms was statistically significant,and the different types of symptoms were classified by cluster analysis,and the data were analyzed using SPSS software.Results Eight qualified papers containing 765 ovarian cancer patients with 18 TCM syndromes were included in this study.The results showed that spleen and kidney deficiency,blood stasis,yang deficiency,phlegm and dampness,and yin deficiency were the highfrequency TCM syndromes to be studied;the mixed syndromes were split and combined with the original single syndrome to obtain 13 single syndromes,which were analyzed by clustering,and the results showed that they were divided into 3 major categories,the first category:spleen deficiency and blood stasis;the second category:dampness,yin deficiency,kidney deficiency,qi stagnation and qi deficiency;the third category:phlegm coagulation,evil heat,liver depression,yang deficiency,blood deficiency and qi depression.The first category showed the greatest frequency of single syndrome.Conclusion According to the analysis of statistical results,deficiency of spleen and kidney,blood stasis,yang deficiency,phlegm-dampness accumulation and yin deficiency in TCM syndrome of ovarian cancer are the high-frequency TCM syndrome that need to be studied.Spleen deficiency and blood stasis have great clinical significance in TCM syndrome differentiation of ovarian cancer.
作者
王雪振
夏雷
Wang Xuezhen;Xia Lei(Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Department of Pathology,Shandong University of Traditional Chinese Medicine,Jinan 250355,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2021年第9期3074-3080,共7页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家自然科学基金委员会面上项目(81673779):从5-HT3受体介导的Ca2+/CaMKII/ERK1/2信号途径探讨小半夏汤防治化疗性恶心呕吐机制,负责人:聂克
山东省科学技术厅山东省重点研发计划(2016CYJS08A01-3):含半夏经方毒-效-物质基础及发展研究,负责人:王世军
关键词
卵巢癌
中医证候
复合型
单证型
证候分布
系统评价
Ovarian cancer
TCM syndrome
Mixed syndrome
Single syndrome
Distribution of syndromes
System review
