摘要
目的基于数据挖掘分析中医药治疗儿童支气管哮喘发作期的组方规律,为临床制定儿童支气管哮喘发作期的处方用药及新药研发提供理论依据。方法检索1988-2018年中国知网、万方数据服务平台、维普数据库、中国生物医学文献数据库中以中医药治疗儿童哮喘发作期的文献,筛选符合标准的文献,构建儿童哮喘发作期方药数据库,进行频数统计、关联规则分析、系统聚类分析。结果共纳入779首方药,涉及药物259味,其中常见证型为热性哮喘证,常用药物40味,使用频次较高的药物为麻黄、苦杏仁、甘草;药物使用以化痰止咳平喘药、解表药、补虚药为主,药味以苦、辛、甘为主;药性以温、寒、平稍多;归经主要归肺、脾经;关联规则分析得出二项关联规则26条,三项关联规则40条,四项关联规则12条;系统聚类分析得出药组10个。结论中医药治疗儿童支气管哮喘方药以化痰平喘、温肺化饮、清肺止咳、补益肺脾、息风解痉、祛瘀通络为主。用药性味体现了苦温、苦寒燥湿化痰,辛温宣肺祛邪,辛开苦降调节气机升降的思想。
Objective Based on the data mining analysis of traditional Chinese medicine in the treatment of children bronchial asthma attack phase of the prescription law,for the clinical formulation of children bronchial asthma attack phase of prescription drugs and new drug research and development to provide a theoretical basis.Methods From 1988 to 2018,literatures of traditional Chinese medicine in the treatment of childhood asthma attack in China National Knowledge Infrastructure(CNKI),WanFang,VIP,SinoMed(CBM)were searched.Literatures that met the criteria were screened.The formulae database of childhood asthma attack was constructed,and frequency statistics,association rule analysis and systematic clustering analysis were conducted.Results A total of 779 prescriptions were included,involving 259 drugs,among which the common syndromes were heat asthma syndrome,40 drugs were commonly used,and ephedra,bitter almond and licorice were frequently used.Drugs used to resolve phlegm cough antiasthmatic drugs,table medicine,tonic drugs mainly,mainly bitter,bitter,sweet;The drug was mostly warm,cold and plain.Meridians mainly belong to lung,spleen meridians.According to the analysis of association rules,there are 26 association rules for two items,40 association rules for three items and 12 association rules for four items.Systematic cluster analysis showed that there were 10 drug groups.Conclusion Traditional Chinese medicine(TCM)treating children’s bronchial asthma mainly includes resolving phlegm and relieving asthma,warming lung and eliminating blood stasis,clearing lung and relieving cough,Benefitting the lung and spleen,relieving wind and spasm,and clearing blood stasis and clearing collaterals.The idea of using the medicinal taste to reflect the bitter temperature,bitter cold dryness and dampness to dissolve phlegm,Xin Wenfa clarifying the air of the lung to dispel evil,xin open bitter fall to adjust the breath rising and falling.
作者
倪萍
杨勤军
杨程
张星星
韩明向
李泽庚
Ni Ping;Yang Qinjun;Yang Cheng;Zhang Xingxing;Han Mingxiang;Li Zegeng(Anhui University of Chinese Medicine,Hefei,230031,China;Institute of Traditional Chinese Medicine Respiratory Diseases,Anhui academy of Chinese Medicine,Hefei,230031,China;First Affiliated Hospital of Anhui University of Chinese Medicine,Hefei,230031,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2020年第7期2276-2284,共9页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家重大疑难疾病临床防治中心-中医药防治重大疑难疾病能力建设项目(国中医药规财函[2014]146号):支气管哮喘,负责人:李泽庚
国家中医药管理局重点研究室建设项目(国中医药函[2009]95号):“国家中医药管理局肺气虚证重点研究室”,负责人:李泽庚
国家自然科学基金委员会面上项目(81874431):基于mTORC1调节自噬相关复合体Beclin1/Bcl-2研究芪玉三龙汤抗非小细胞肺癌机制,负责人:李泽庚
关键词
支气管哮喘
中医药治疗
数据挖掘
用药规律
儿童
Bronchial asthma
Traditional Chinese medicine treatment
Data mining
Medication regularity
Children
