摘要
山豆根在《中国药典》中记载为"有毒"。文献报道其毒性成分主要为苦参碱和氧化苦参碱,苦参碱毒性大于氧化苦参碱。通过对其干燥加工炮制方法及用法与毒性关系进行回顾性研究,提出直接用鲜山豆根切制饮片的思路并进行实践。鲜山豆根采挖后快速清洗,快速晾干表面水分,快速横切成5 mm厚片,快速干燥,其后检测发现苦参碱含量为0.031%,在一定程度上起到了控制和减少苦参碱含量以降低毒性的作用。
Shandougen Radix Sophorae Tonkin, RST was recorded as "toxic" in the Chinese Pharmacopoeia(ChP). According to the literature, matrine and oxymatrine mainly contribute to its toxicity, and the former is more poisonous. A retrospective study was carried out on the relationship between its drying and concocting processing methods, usage and toxicity, and the idea of directly slicing fresh RST into decoction pieces was put forward and practiced. Fresh RST was quickly cleaned after harvest, the surface moisture was quickly dried up, and RST was quickly sliced into 5 mm pieces. After a complete second fast-drying, the matrine content was 0.031%. The whole process of RST played a role in controlling and reducing matrine content to lower toxicity to a certain degree.
作者
周沁阳
马克坚
赵景云
龙江兰
何元凯
宋娜丽
曹玺
ZHOU Qinyang;MA Kejian;ZHAO Jingyun;LONG Jianglan;HE Yuankai;SONG Nali;CAO Xi(School of Traditional Chinese Pharmacy,China Pharmaceutical University,Nanjing 211198,China;The Institution of Yunnan Traditional Chinese Medicine and Materia Medical,Kunming 650223,Yunnan,China;Wenshan Academy of Food and Drug Inspection,Wenshan 663099,Yunnan,China)
出处
《上海中医药杂志》
2020年第5期58-60,共3页
Shanghai Journal of Traditional Chinese Medicine
基金
云南省重大科技专项(生物医药2018110509)
云南省中医中药研究院院级项目(ZYY2018018)
关键词
山豆根
鲜切晒干
苦参碱
氧化苦参碱
中药毒性
Radix Sophorae Tonkinesis
fresh-cut and dry-out
matrine
oxymatrine
Chinese traditional medicine toxicity
