摘要
目的:探究消导便通汤联合枯草杆菌二联活菌颗粒治疗儿童便秘的临床效果。方法:选择2017年5月~2020年7月泰州市第二人民医院收治的便秘患儿98例,采用随机数字表法分为观察组与对照组,各49例。对照组给予枯草杆菌二联活菌颗粒治疗,观察组给予消导便通汤联合枯草杆菌二联活菌颗粒治疗。比较2组治疗前后的排便改善情况、中医证候积分、临床疗效、炎症因子水平及不良反应发生情况。结果:治疗前2组间排便频率、排便时间比较,差异均无统计学意义(P>0.05),治疗后2组排便频率、排便时间均降低,且观察组低于对照组(P<0.05);治疗前2组间主症积分、次症积分及总积分比较,差异均无统计学意义(P>0.05),治疗后2组上述证候积分均降低,且观察组低于对照组(P<0.05);观察组治疗总有效率高于对照组(P<0.05);治疗前2组血清肿瘤坏死因子-α(TNF-α)和白细胞介素-8(IL-8)水平比较,差异均无统计学意义(P>0.05),治疗后2组血清TNF-α、IL-8水平均降低,且观察组低于对照组(P<0.05);观察组与对照组总不良反应发生率比较无明显差异(P>0.05)。结论:消导便通汤联合枯草杆菌二联活菌颗粒治疗儿童便秘的临床效果显著,可有效改善患儿便秘症状,降低炎症因子水平,且不良反应发生率低,值得推广。
Objective:To investigate the clinical efficacy of Xiaodaobiantong decoction combined with Bacillus subtilis dual live bacteria particles in treating constipation in children.Methods:Ninety-eight children with constipation who were admitted to the Second People's Hospital of Taizhou City between May 2017 and July 2020 were enrolled in this study.They were randomly assigned to the observation group or the control group using the random number table method,with 49 cases in each group.The control group was given Bacillus subtilis dual live bacteria particles,while the observation group was treated with a combination of Xiaodaobiantong decoction and Bacillus subtilis dual live bacteria particles.The improvement in bowel movements,TCM syndrome score,clinical efficacy,inflammatory factor level,and adverse reactions were compared between the two groups before and after treatment.Results:Before treatment,there was no statistically significant difference in the frequency and duration of defecation between the two groups(P>0.05).After treatment,the frequency and duration of defecation decreased in both groups,with the observation group showing a greater improvement than the control group(P<0.05).Before treatment,there was no statistically significant difference in the primary,secondary,and total TCM syndrome scores between the two groups(P>0.05).After treatment,the scores decreased in both groups,and the observation group showed a greater improvement than the control group(P<0.05).The overall efficacy of the treatment was higher in the observation group than in the control group(P<0.05).There was no significant difference in the incidence of total adverse reactions between the observation group and the control group(P>0.05).Conclusion:Xiaodaobiantong decoction combined with Bacillus subtilis dual live bacteria particles is an effective treatment for constipation in children,which can effectively improve the symptoms of constipation and reduce the level of inflammatory factors in children with a low incidence of adverse reactions,and is worth promoting.
作者
高峰
李荣荣
陈凤展
GAO Feng;LI Rongrong;CHEN Fengzhan(Department of Pediatrics,Taizhou Second People's Hospital,Taizhou Jiangsu 225500,China)
出处
《四川中医》
2023年第4期81-84,共4页
Journal of Sichuan of Traditional Chinese Medicine
基金
江苏省中医药局科技项目(编号:LZ13189)
关键词
儿童便秘
枯草杆菌二联活菌颗粒
消导便通汤
证候积分
Children constipation
Bacillus subtilis dual live bacteria particles
Xiaodaobiantong Decoction
Syndrome integral
