摘要
目的:研究分析甘草泻心汤加减联合康复新液治疗对溃疡性直肠炎患者症状积分、免疫功能及不良反应的影响。方法:对我院2018年6月至2020年6月期间收治的116例溃疡性直肠炎患者的资料进行回顾性分析。根据治疗方式不同分为对照组(n=57)与研究组(n=59)。对照组予以西医常规治疗,研究组在西医治疗基础上予以甘草泻心汤加减联合康复新液治疗。比较两组临床疗效、症状积分[参考《炎症性肠病诊断治疗规范的共识意见》进行症状评分,主要有腹泻、腹痛、粘液脓血便、里急后重四项]、免疫功能[包括:红细胞沉降率(erythrocyte sedimentation Rate,ESR)、免疫球蛋白G(Immunoglobulin G,IgG)、C反应蛋白(C-reactive protein,CRP)]及不良反应。结果:(1)研究组临床总有效率(96.61%)显著高于对照组(89.47%),差异存在统计学意义(P<0.05);(2)治疗后,两组患者的症状积分均较治疗前下降,且以研究组下降最为显著(P<0.05);(3)治疗后,两组ESR、IgG、CRP水平均较治疗前下降,且以研究组下降最为显著(P<0.05);(4)对照组不良反应发生率(10.53%)高于研究组不良反应发生率(3.39%),两组对比差异存在统计学意义(P<0.05)。结果:甘草泻心汤加减联合康复新液治疗溃疡性直肠炎的临床疗效好,可有效改善患者症状积分和免疫功能,安全性佳,具有临床使用价值。
Objective:To analyze the effect of Gancao Xiexin Decoction combined with Kangfuxin Liquid treatment on symptom score,immune function and adverse reactions for patients with ulcerative proctitis.Methods:The data of 116 patients with ulcerative proctitis admitted to our hospital from June 2018 to June 2020 were retrospectively analyzed.According to different treatment methods,they were divided into a controlled group(n=57)and a study group(n=59).The controlled group was treated with conventional western medicine treatment,and the study group was supplemented with Gancao Xiexin Decoction combined with Kangfuxin Liquid.The clinical efficacy and symptom scores[refer to the“Consensus on the Diagnosis and Treatment of Inflammatory Bowel Disease”,mainly including diarrhea,abdominal pain,mucopurulent bloody stool,tenesmus four items],immune function[including:erythrocyte sedimentation rate(ESR),immunoglobulin G(IgG),C-reactive protein(CRP)]and adverse reactions between the two groups were compared.Results:(1)The total clinical effective rate of the study group(96.61%)was significantly higher than that of the controlled group(89.47%),and the difference was statistically significant(P<0.05).(2)After treatment,the symptom scores of the two groups decreased,and the decreasing in the study group was the most significant(P<0.05).(3)After treatment,the levels of ESR,IgG,and CRP in the two groups decreased,and the decrease in the study group was the most significant(P<0.05).(4)The incidence of adverse reactions in the controlled group(10.53%)was higher than that in the study group(3.39%),and the difference between the two groups was statistically significant(P<0.05).Conclusion:Using Gancao Xiexin Decoction combined with Kangfuxin Liquid has a good clinical effect in the treatment of ulcerative proctitis,can effectively improve the patient’s symptom score and immune function,has good safety,and has clinical value.
作者
吴文
黄妹
徐华光
WU Wen;HUANG Mei;XU Huaguang(Department of Pharmacy,the People's Hospital of Chengmai County,Haikou Hai'nan 571900,China;Department of Pharmacy,Haikou Municipal Hospital of Traditional Chinese Medicine,Haikou Hai'nan 570000,China;Department of Traditional Chinese Medicine,the People's Hospital of Chengmai County,Haikou Hai'nan 571900,China)
出处
《四川中医》
2022年第7期107-110,共4页
Journal of Sichuan of Traditional Chinese Medicine
基金
海南省卫生厅科研项目(编号:1801032054A2035)
关键词
甘草泻心汤加减
康复新液
溃疡性直肠炎
症状积分
免疫功能
Gancao Xiexin Decoction
Kangfuxin Liquid
Ulcerative proctitis
Symptom score
Immune function
