摘要
目的:探讨二冬汤加减联合甲巯咪唑治疗阴虚火旺型甲状腺功能亢进症的临床疗效。方法:选取2017年4月~2019年12月北京市和平里医院收治的甲状腺功能亢进症患者95例,按照随机数字表法将95例患者分为对照组(n=47)和观察组(n=48)。对照组给予甲巯咪唑治疗,观察组给予二冬汤加减联合甲巯咪唑治疗治疗,两组均连续治疗4周。治疗后统计两组的临床总有效率;比较两组治疗前后的中医症候评分、甲状腺肿大积分、突眼积分及血清三碘甲状腺原氨酸(T3)、四碘甲状腺原氨酸(T4)、促甲状腺激素(TSH)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GPX)、丙二醛(MDA)水平;另外比较两组治疗过程中不良反应发生率。结果:观察组的临床总有效率明显比对照组高,差异有统计学意义(χ^(2)值=4.540,P=0.033)。两组治疗后中医症候评分、甲状腺肿大积分及突眼积分均明显比治疗前小(P<0.05),同时观察组治疗后中医症候评分、甲状腺肿大积分及突眼积分均明显比对照组小(P<0.05)。两组治疗后血清T3、T4水平均明显比治疗前低(P<0.05),血清TSH水平均明显比治疗前高(P<0.05),同时观察组治疗后血清T3、T4水平均明显比对照组低(P<0.05),血清TSH水平明显比对照组高(P<0.05)。两组治疗后血清SOD、GPX水平均明显比治疗前高(P<0.05),血清MDA水平均明显比治疗前低(P<0.05),同时观察组治疗后血清SOD、GPX水平均明显比对照组高(P<0.05),血清MDA水平明显比对照组低(P<0.05)。治疗期间,两组不良反应发生率比较,差异无统计学意义(χ^(2)值=0.101,P=0.751)。结论:二冬汤加减联合甲巯咪唑治疗阴虚火旺型甲状腺功能亢进症的临床疗效显著,能够明显减轻临床症状,调节甲状腺激素水平,其治疗机制可能与抗氧化功能有关,且安全性较好。
Objective:To investigate the clinical efficacy of using Erdong Decoction combined with Thiamazole in the treatment of Yin-deficiency and fire-hyperactivity type hyperthyroidism.Methods:According to the random table method,95 cases of patients with Yin-deficiency and fire-hyperactivity type hyperthyroidism were divided into a controlled group(n=47)and a research group(n=48).The patients in the controlled group were treated with Thiamazole,while the patients in the research group were treated with Erdong Decoction combined with Thiamazole,the two groups were treated for 4 weeks.The clinical total effective rate of the two groups after treatment was compared.The TCM syndrome scores,goiter scores,exophthalmus scores and serum levels of T3,T4,TSH,SOD,GPX,MDA of the two groups of patients before and after treatment were determined.In addition,the adverse reaction incidence of two groups of patients were observed.Results:The total effective rate of the research group was significantly higher than that of the controlled group(χ^(2)=4.540,P=0.033).The TCM syndrome scores,goiter scores,exophthalmus scores and serum levels of T3,T4,MDA of the two groups were significantly lower than before treatment,the serum levels of TSH,SOD,GPX of the two groups were significantly higher than before treatment,and that of the research group were significantly better than that of the controlled group(P<0.05).During treatment,there was no significantly difference of the adverse reaction rate of the two groups(χ^(2)=0.101,P=0.751).Conclusion:The clinical curative effect of using Erdong Decoction combined with Thiamazole in the treatment of Yin-deficiency and fire-hyperactivity type hyperthyroidism is significantly,which can significantly reduce the clinical symptoms,regulates thyroid hormone levels,its therapeutic mechanism may be related to antioxidant function and has good safty.
作者
张春芳
孙海波
顾权
杨科
ZHANG Chunfang;SUNHaibo;GU Quan(Department of Emergency,Beijing Hepingli Hospital,Beijing 100013,China;Department of Thyroid and Breast Surgery,Zouping Municipal Hospital of Traditional Chinese Medicine,Zouping Shandong 256200,China)
出处
《四川中医》
2022年第6期113-117,共5页
Journal of Sichuan of Traditional Chinese Medicine
基金
北京市科学研究重点研发计划项目(编号:Z814259-76)
