摘要
缺血性卒中占脑卒中的60%~80%,是脑卒中的重要类型。血脑屏障破坏是缺血性卒中重要的病理特征。干细胞治疗缺血性卒中已显示出令人瞩目的潜力。本文从保护血脑屏障角度,阐述骨髓间充质干细胞、内皮祖细胞和少突胶质前体细胞移植治疗缺血性卒中的机制,涉及免疫调节和旁分泌途径等相关机制。
Ischemic stroke accounts for 60%-80%of stroke and is an important type of stroke.Damage of blood-brain barrier is an important pathological feature of ischemic stroke.Stem cells have shown remarkable potential in the treatment of ischemic stroke.From the perspective of protecting blood-brain barrier,this paper expounds the mechanism of transplantation of bone marrow mesenchymal stem cells,endothelial progenitor cells and oligodendrocyte precursor cells in the treatment of ischemic stroke,involving immune regulation and paracrine pathway.
作者
王丽萍
谢冲
管阳太
WANG Liping;XIE Chong;GUAN Yangtai(Department of Neurology,Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China)
出处
《神经病学与神经康复学杂志》
2021年第1期26-31,共6页
Journal of Neurology and Neurorehabilitation
基金
上海市科学技术委员会“科技创新行动计划”基础研究领域项目(20JC1412000)
关键词
缺血性卒中
干细胞移植
血脑屏障
Ischemic stroke
Stem cell transplantation
Brain-blood barrier
