摘要
目的调查电离辐射对心血管内科医务人员甲状腺功能的可能影响。方法以46例暴露于电离辐射的心血管内科医务人员为调查对象。收集调查对象人口学特征,采用化学发光法检测血清游离三碘甲状酪氨酸(free triiodothyronine,fT3)、游离四碘甲状酪氨酸(free thyroxine,fT4)、促甲状腺激素(thyroid-stimulating hormone,TSH)水平,采用热释光个人剂量计测定2019年辐射个人剂量当量[H(10)]及2015—2019年5年累计H(10)剂量。采用精准logistic回归模型评价甲状腺功能改变与年龄、性别、既往甲状腺疾病病史、甲状腺疾病家族史、工作岗位、工作年限、既往辐射暴露史等人口学特征的关联。结果调查对象亚临床甲状腺功能减退症(血清TSH水平升高,但fT3和fT4水平无变化)发生率为6.5%。2019年,调查对象H(10)剂量为0~4.5 mSv,平均剂量(0.2±0.7)mSv,中位剂量0 mSv;2015—2019年5年累计H(10)剂量为0~11.6 mSv,平均剂量(0.8±2.3)mSv,中位剂量0 mSv。精准logistic回归分析显示,调查对象甲状腺功能异常与年龄、性别、甲状腺疾病家族史、既往甲状腺疾病病史、工作岗位、工作年限、既往辐射暴露史等人口学特征均无统计学关联(P均>0.05)。结论长期暴露于低剂量电离辐射可能增加心血管内科医务人员亚临床甲状腺功能减退症发生风险.
Objective To examine the possible effect of ionizing radiation on thyroid function among medical workers in the department of cardiovascular medicine.Methods Forty-six medical workers in the department of cardiovascular medicine with exposure to ionizing radiation were enrolled as the study subjects.Subjects’demographic features were collected.Serum free triiodothyronine(fT3),free thyroxine(fT4),and thyroid-stimulating hormone(TSH)levels were measured using chemiluminescence assay,and the annual personal dose equivalent(H(10))received in 2019 and the fiver-year cumulative H(10)from 2015 to 2019 were measured using a thermoluminescent personal dosimeter.The associations of altered thyroid functions with subjects’age,sex,previous history of thyroid diseases,family history of thyroid diseases,working post,work seniority,and previous history of exposure to ionizing radiation were evaluated using an exact logistic regression model.Results The incidence of subclinical hypothyroidism(elevated serum TSH level without alteration in fT3 or fT4 level)was6.5%among the study subjects.The H(10)was 0 to 4.5 mSv among the subjects in 2019,with a mean dose of(0.2±0.7)mSv and a median dose of 0 mSv,and the five-year cumulative H(10)from 2015 to 2019 was 0 to 11.6 mSv,with a mean dose of(0.8±2.3)mSv and a median dose of 0 mSv.The exact logistic regression analysis showed that the altered thyroid functions were not significantly associated with age,sex,previous history of thyroid diseases,family history of thyroid diseases,working post,work seniority,or previous history of exposure to ionizing radiation(all P>0.05).Conclusion Long-term exposure to low-dose ionizing radiation may be associated with an increased risk of subclinical hypothyroidism among medical workers in the department of cardiovascular medicine.
作者
徐汉丽
刘丹
XU Hanli;LIU Dan(904 Hospital of PLA Cardiovascular Department,Wuxi 214044 China)
出处
《中国辐射卫生》
2022年第5期626-630,共5页
Chinese Journal of Radiological Health
