摘要
目的:观察复方玄驹胶囊联合西药治疗类风湿性关节炎(RA)肾阳虚证的临床疗效。方法:选取120例RA肾阳虚证患者,以随机数字表法分为对照组和治疗组各60例。对照组给予西药(来氟米特片、甲氨蝶呤片)治疗,治疗组在对照组基础上给予复方玄驹胶囊治疗,2组均治疗3个月。比较2组临床疗效,中医证候、视觉模拟评分法(VAS)、类风湿关节炎疾病活动性(DAS28)评分,血清抗环瓜氨酸肽抗体(抗-CCP)、红细胞沉降率(ESR)、类风湿因子(RF)水平。结果:治疗后,治疗组总有效率88.33%,高于对照组73.33%(P<0.05)。2组关节冷痛而肿、关节屈伸不利、晨僵、腰膝酸软、下肢浮肿、夜尿频多评分均较治疗前降低(P<0.05),治疗组上述6项中医证候评分均低于对照组(P<0.05)。2组VAS、DAS28评分均较治疗前降低(P<0.05),治疗组VAS、DAS28评分均低于对照组(P<0.05)。2组血清抗-CCP、ESR、RF水平均较治疗前降低(P<0.05),治疗组血清抗-CCP、ESR、RF水平均低于对照组(P<0.05)。结论:复方玄驹胶囊联合西药治疗RA肾阳虚证的疗效优于单独使用西药治疗,可降低血清抗-CCP、ESR、RF水平,缓解关节炎症,减轻患者的临床症状。
Objective:To observe the clinical effect of Compound Xuanju Capsules combined with western medicine for rheumatoid arthritis(RA)with kidney yang deficiency syndrome.Methods:A total of 120 cases of RA patients with kidney yang deficiency syndrome were selected and divided into the control group and the treatment group according to the random number table method,with 60 cases in each group.The control group was treated with western medicine(Leflunomide Tablets and Methotrexate Tablets),and the treatment group was additionally treated with Compound Xuanju Capsules based on the treatment of the control group.Both groups were treated for 3 months.The clinical effects,the scores of traditional Chinese medicine(TCM)syndrome,Visual Analogue Scale(VAS)and Disease Activity Scores of rheumatoid arthritis(DAS28),and the levels of anti-cyclic citrullinated peptide antibody(anti-CCP),erythrocyte sedimentation rate(ESR)and rheumatoid factor(RF)in serum were compared between the two groups.Results:After treatment,the total effective rate was 88.33%in the treatment group,higher than that of 73.33%in the control group(P<0.05).The scores of cold,pain and swelling in joints,poor flexor extension in joints,morning stiffness,soreness and weakness in waist and knees,edema of lower limbs,and frequent and much nocturia in the two groups were decreased when compared with those before treatment(P<0.05),and the above six TCM syndrome scores in the treatment group were lower than those in the control group(P<0.05).The scores of VAS and DAS28 in the two groups were decreased when compared with those before treatment(P<0.05),and the scores of VAS and DAS28 in the treatment group were lower than those in the control group(P<0.05).The levels of anti-CCP,ESR,and RF in serum in the two groups were decreased when compared with those before treatment(P<0.05),and the levels of anti-CCP,ESR,and RF in serum in the treatment group were lower than those in the control group(P<0.05).Conclusion:Compound Xuanju Capsules combined with western medicine for RA with kidney yang deficiency syndrome has a better curative effect than the simple treatment of western medicine.And it can reduce the levels of anti-CCP,ESR,and RF in serum,relieve joint inflammation,and alleviate clinical symptoms of patients.
作者
虞丽诗
YU Lishi(Lishui Municipal Central Hospital,Lishui Zhejiang 323000,China)
出处
《新中医》
CAS
2023年第20期89-93,共5页
New Chinese Medicine
关键词
类风湿性关节炎
肾阳虚证
复方玄驹胶囊
来氟米特片
甲氨蝶呤片
中医证候
类风湿因子
Rheumatoid arthritis
Kidney yang deficiency syndrome
Compound Xuanju Capsules
Leflunomide Tablets
Methotrexate Tablets
Traditional Chinese medicine syndrome
Rheumatoid factor
