摘要
目的:基于数据挖掘技术探讨陈为教授治疗岭南地区原发性头痛的用药规律。方法:收集2016年1月—2021年12月在陈为教授门诊治疗的岭南地区原发性头痛患者的病历资料。采用中医传承辅助平台(V3.0)提供的频次分析、关联规则分析、聚类分析等数据挖掘方法,统计处方中的用药频次,分析与挖掘药物之间的关联规则和核心组合等。结果:共收录处方200首,涉及152味中药,其中用药频次较高的有甘草、白芷、葛根、柴胡、党参、牛膝、白芍、陈皮、茯苓、泽泻等。药性以温为主,平、寒次之。药味以甘为主,辛、苦次之。药物归经分布较广,涉及十二经脉,其中频次居前5的为肺、脾、胃、肝、心经。常用的药物组合有甘草-白芷、甘草-白芍、葛根-柴胡、陈皮-泽泻、白芷-白芍、柴胡-茯苓、柴胡-白术等。形成3种处方聚类药物核心组合,分别为“党参、牛膝、泽泻、陈皮、甘草”“白芷、茯苓、葛根、白芍、甘草”“白术、川芎、蔓荆子、白芷、甘草”。结论:陈为教授治疗岭南地区原发性头痛以“温、补、和”三法为主,“扶正御邪、平调阴阳”学术思想贯穿治疗始终。
Objective:To discuss the medication rules of Professor CHEN Wei treating primary headache in Lingnan area based on data mining.Methods:The medical history of patients with primary headache in Lingnan area receiving treatment in the clinic of Professor CHEN from January 2016 to December 2021 was collected.The medicine frequency was summed up and the association rules and core combination among Chinese medicines were analyzed by the data mining methods on Chinese Medicine Inheritance Assistance Platform System(V3.0),including frequency analysis,association rule analysis and cluster analysis.Results:A total of 200 prescriptions were included and 152 Chinese medicinals involved.Among them,the Glycyrrhizae Radix et Rhizoma,Angelicae Dahuricae Radix,Puerariae Lobatae Radix,Bupleuri Radix,Codonopsis Radix,Achyranthis Bidentatae Radix,Paeoniae Radix Alba,Citri Reticulatae Pericarpium,Poria and Alismatis Rhizoma were used more frequently.The main nature of above Chinese medicinals is warm,followed by mild and cold,and the main flavor is sweet,followed by acrid and bitter.With wide channel entries involving twelve meridians,the top 5 in frequency are lung meridian,spleen meridian,stomach meridian,liver meridian and heart meridian.The commonly-used combinations are Liquiritiae Radix-Angelicae Dahuricae,Liquiritiae Radix-Paeoniae Radix Alba,Puerariae Lobatae Radix-Bupleuri Radix,Citri Reticulatae Pericarpium-Alismatis Rhizoma,Angelicae Dahuricae Radix-Paeoniae Radix Alba,Bupleuri Radix-Poria,and Bupleuri Radix-Atractylodis Macrocephalae Rhizoma.Three types of cluster core combinations of formula,including“Codonopsis Radix,Achyranthis Bidentatae Radix,Alismatis Rhizoma,Citri Reticulatae Pericarpium and Glycyrrhizae Radix et Rhizoma”“Angelicae Dahuricae Radix,Poria,Puerariae Lobatae Radix,Paeoniae Radix Alba and Glycyrrhizae Radix et Rhizoma”and“Atractylodis Macrocephalae Rhizoma,Chuanxiong Rhizoma,Viticis Fructus,Angelicae Dahuricae Radix and Glycyrrhizae Radix et Rhizoma”.Conclusion:Professor CHEN mainly used three methods of“warming,supplementing and harmonizing”to treat primary headache in Lingnan area,and the academic thought of“reinforcing the healthy qi to guard against pathogens,and harmonizing yin and yang”is throughout the whole treatment.
作者
葛成成
董金典
宋卓悦
陈为
GE Chengcheng;DONG Jindian;SONG Zhuoyue;CHEN Wei(Guangzhou University of Chinese Medicine,Guangzhou Guangdong 510405,China;The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou Guangdong 510405,China)
出处
《新中医》
CAS
2023年第20期6-11,共6页
New Chinese Medicine
基金
广东省自然科学基金面上项目(2022A1515010337)
广州中医药大学“双一流”与高水平大学学科协同创新团队项目(2021XK01)
关键词
原发性头痛
岭南地区
数据挖掘
用药规律
陈为
Primary headache
Lingnan area
Data mining
Medication rules
CHEN Wei
