摘要
目的探讨经导管动脉化疗栓塞术(TACE)联合康复干预对中晚期肝癌患者血清生物学指标、术后睡眠质量及康复效果的影响。方法将86例中晚期肝癌患者按随机信封法分为对照组43例和观察组43例。对照组接受TACE治疗,观察组在其基础上接受康复干预。比较两组干预前后血清生物学指标(甲胎蛋白、血管内皮生长因子)水平、匹兹堡睡眠质量评分、生活质量评分、住院时间和不良反应发生情况。结果干预后两组血清甲胎蛋白(AFP)、血管内皮生长因子(VEGF)水平和睡眠质量评分均较治疗前显著下降(P<0.05),两组AFP、VEGF水平比较差异无统计学意义(P>0.05)。观察组睡眠质量评分低于对照组(P<0.05),生活质量评分高于对照组(P<0.05),住院时间短于对照组(P<0.05)。治疗期间两组患者均有恶心呕吐、头晕、腹痛腹泻、血压升高、皮疹等不良反应,经对症处理后均有效控制。结论经导管动脉化疗栓塞术联合康复干预能降低中晚期肝癌患者血清AFP、VEGF水平,改善睡眠质量和生活质量,缩短住院时间,促进康复。
Objective To explore the effect of transcatheter arterial chemoembolization(TACE)combined with rehabilitation intervention on serum biological indicators,postoperative sleep quality and rehabilitation effect in patients with advanced liver cancer.Methods 86 patients with advanced liver cancer were selectedaccording to random envelope method and they were divided into 43 cases in the control group and 43 cases in the observation group.The control group received TACE treatment,and the observation group received rehabilitation intervention based on it.The levels of serum biological indexes(alpha-fetoprotein,vascular endothelial growth factor),Pittsburgh sleep quality score,quality of life score,hospital stay and adverse reactions were compared between the two groups before and after intervention.Results After intervention,the levels of serum alpha-fetoprotein(AFP),vascular endothelial growth factor(VEGF)and sleep quality scores were significantly lower than those before treatment(P<0.05).There was no statistically significant difference in the levels of AFP and VEGF between the two groups(P>0.05).The sleep quality score of the observation group was lower than the control group(P<0.05),the quality of life score was higher than the control group(P<0.05),and the hospital stay was shorter than the control group(P<0.05).During treatment,both groups of patients had nausea and vomiting,dizziness,abdominal pain and diarrhea,increased blood pressure,skin rash and other adverse reactions,which were effectively controlled after symptomatic treatment.Conclusion Transcatheter arterial chemoembolization combined with rehabilitation intervention can reduce serum AFP and VEGF levels in patients with advanced liver cancer,improve sleep quality and quality of life,shorten hospital stay,and promote rehabilitation.
作者
李晓琴
王小兰
LI Xiaoqin;WANG Xiaolan(Taizhou People's Hospital,Taizhou 225300,China)
出处
《中国全科医学》
CAS
北大核心
2020年第S02期255-257,共3页
Chinese General Practice
关键词
经导管动脉化疗栓塞术
康复干预
中晚期肝癌
睡眠质量
康复效果
Transcatheter arterial chemoembolization
Rehabilitation intervention
Advanced liver cancer
Sleep quality
Rehabilitation effect
