摘要
目的探讨DNA甲基化标志物5mC、5hmC、5fC和5caC在结肠癌中的表达及临床意义。方法在包括100例结肠癌组织和60例癌旁正常组织的结肠癌组织芯片上进行5m C、5hm C、5f C、5ca C免疫组化检测,比较上述4种指标在结肠癌与癌旁正常组织中的表达。结果结肠癌组织5m C、5hm C、5f C、5ca C表达均明显低于癌旁组织,差异有统计学意义(P<0.05)。结论DNA甲基化标记物5m C、5hm C、5f C、5ca C可能成为结肠癌诊断的新型标记物。
Objective To investigate the expression and clinical significance of DNA methylation 5mC,5hmC,5fC and 5caC in colon cancer.Methods The expression of 5mC,5hmC,5fC and 5caC in 100 cases of colon cancer tissues and 60 cases of adjacent normal tissues were detected by immunohistochemistry.Results The expressions of 5mC,5hmC,5fC and 5caC in colon cancer tissues were significantly lower than those in adjacent tissues,and the differences were statistically significant(P<0.01).Conclusion DNA methylation 5mC,5hmC,5fC and 5caC may be novel markers for the diagnosis of colon cancer.
作者
闫新欣
张熙洋
席少枝
王春琦
高云
茹松伟
林菁榕
YAN Xinxin;ZHANG Xiyang;XI Shaozhi;WANG Chunqi;GAO Yun;RU Songwei;LIN Jingrong(Geriatric Department,Aerospace Central Hospital,Beijing 100049,China;Endocrinology Department,Aerospace Central Hospital,Beijing 100049,China;Education Department,Aerospace Central Hospital,Beijing 100049,China)
出处
《中国全科医学》
CAS
北大核心
2020年第S02期184-185,共2页
Chinese General Practice
