摘要
目的:探讨天麻素注射液的临床安全性。方法:计算机检索目前公开发表的天麻素注射液随机进行对照研究;采用RevMan 5.3软件进行Meta分析。结果:最终纳入随机对照临床试验29篇,纳入研究患者共2961例,其中天麻素注射液试验组共1492例,发生不良反应67例;对照组1469例,发生不良反应67例。Meta结果显示天麻素注射液试验组不良反应发生率(4.49%)与对照组(4.56%)比较,差异无统计学意义(P=0.92)。Meta分析结果显示,各研究之间不存在异质性(P=0.49,I2=0),故采用固定效应模型分析,RR值及95%的可信区间为0.98(0.69,1.40)。结论:天麻素注射液是一种较为安全的药物。
Objective:This study is aimed toevaluate the clinical safety of Gastrodin Injection.Methods:Electronic search was conducted for randomized clinical trials on Gastrodin Injection.Meta-analyses were performed by RevMan 5.3 software.Results:29 trials among 2961 patients met the inclusion criteria(Gastrodin injectiongroup:1492,control group:1469).There was no significant difference between the two groups on the rate of adverse reactions(Gastrodin injectiongroup:4.49%,control group:4.56%,P=0.92).The result of Mata analysis showed that there was no heterogenicity in the study(P=0.49,I2=0).Analysis of fixed effect model showed RR value and 95%of credibility interval was 0.98(0.69,1.40).Conclusion:The safety of Gastrodin injection is a relatively high.
作者
刘德秀
刘青章
李来云
赵文
Liu Dexiu;Liu Qingzhang;Li Laiyun;Zhao Wen(Qiaotou Traditional Chinese Medicine Hospital of Datong,810100;The Second People’s Hospital of Datong,810100;Xincheng Health Center of Xining,810100)
出处
《青海医药杂志》
CAS
2021年第1期1-6,共6页
Qinghai Medical Journal
