摘要
【目的】探讨自然流产史未孕女性的血清同型半胱氨酸(homocysteine,HCY)、D-二聚体(D-Dimer)、纤维蛋白原(fibrinogen,FIB)水平的相关性及B族维生素治疗前后的血清学变化。【方法】回顾性研究自2019年1月至2019年10月在本院门诊就诊,行孕前检查的非妊娠妇女124例。分为自然流产组61例和正常组63例。两组在血清HCY、D-Dimer、FIB水平方面进行比较及相关性研究,并根据HCY水平不同分为A组和B组,进行药物治疗前后对比研究。【结果】自然流产组的HCY、DDimer及FIB水平均高于正常组差异有统计学意义(P<0.05);且三者呈正相关关系[r(HCY与FIB)=0.64;r(HCY与D-Dimer)=0.60;r(FIB与D-Dimer)=0.63](P<0.05);治疗后A组的血清HCY水平明显低于治疗前A组水平(P<0.05),而治疗后A组的血清FIB及D-Dimer水平与治疗前A组水平比较,差异无统计学意义(P>0.05)。治疗后B组的血清HCY、FIB及D-Dimer水平均明显低于治疗前B组水平,差异有统计学意义(P<0.05)。【结论】血清高HCY、D-Dimer及FIB水平可能是导致自然流产血栓前状态的高危因素,补充B族维生素对降低高同型半胱血症效果明显。
【Objective】To investigate the correlation of serum levels of homocysteine(HCY),D-dimer and fibrinogen(FIB)in non pregnant women with a history of spontaneous abortion and serological changes before and after the treatmemt of B vitamins.【Methods】A retrospective study was conducted on 124 non pregnant women who were examined before pregnancy from January 2019 to October 2019.They were divided into spontaneous abortion group(61 cases)and normal group(63 cases).The levels of HCY,Ddimer and FIB were compared and correlated between the two groups.According to the different levels of HCY,the paitents in the two groups were divided into group A and group B before and after the drug treatment,and the level of HCY and FIB were compared.【Results】The levels of HCY,D-dimer and FIB in the spontaneous abortion group were significantly higher than those in the normal group(P<0.05),and there was a positive correlation between them[R(Hcy and FIB)=0.64;R(Hcy and D-dimer)=0.60;R(FIB and Ddimer)=0.63,P<0.05].After treatment,the level of serum HCY in the group A was significantly lower than that in the group A before treatment(P<0.05),while after treatment,the levels of serum FIB and D-dimer in the group A were significantly lower than those in the group A before treatment.There was no significant difference(P>0.05).The levels of HCY,FIB and D-dimer in the group B after treatment were significantly lower than those before treatment(P<0.05).【Conclusion】The high serum levels of HCY,D-Dimer and FIB may be the high risk factors of prethrombotic state of spontaneous abortion.The supplementation of B vitamins is obviously effective to reduce hyperhomocysteinemia.
作者
孙旸
孔祥玲
侯海燕
董渠龙
孙青
SUN Yang;KONG Xiang-ling;HOU Hai-yan;DONG Qu-long;SUN Qing(Department of Gynecology and Obstetrics,Characteristic Medical Center of PAP,Tianjin 300162,China)
出处
《武警后勤学院学报（医学版）》
CAS
2021年第1期36-39,共4页
Journal of Logistics University of PAP（Medical Sciences）
