摘要
目的探讨泼尼松联合丙硫氧嘧啶治疗甲状腺功能亢进症的效果。方法选择2019-01至2021-06解放军总医院第三医学中心收治的甲状腺功能亢进症患者80例,按照随机数字表法随机分为对照组与观察组,每组40例。对照组采用丙硫氧嘧啶治疗,口服,3次/d,每次20 mg。观察组采用丙硫氧嘧啶联合泼尼松治疗,丙硫氧嘧啶给药方法与对照组一致,泼尼松口服,3次/d,每次10 mg。持续治疗12周停药,比较两组患者的总有效率、钙磷代谢指标、血清激素水平、生活质量评分、肝肾功能指标、不良反应发生率。结果观察组总有效率为97.50%,高于对照组的85.00%(P<0.05)。治疗后,观察组的血钙、血磷水平分别为(1.95±0.20)mmol/L、(1.20±0.29)mmol/L,均低于对照组(P<0.05)。治疗后,观察组甲状旁腺激素、游离三碘甲腺原氨酸、游离甲状腺素分别为(230.37±74.92)pg/ml、(12.86±3.57)pmol/L、(17.92±5.73)pmol/L,均低于对照组(P<0.05),观察组促甲状腺激素为(2.04±0.55)mU/L,高于对照组(P<0.05)。治疗后,观察组生活质量中生理、心理、环境、社会关系的评分分别为(85.07±6.29)分、(84.98±5.97)分、(84.05±6.48)分、(85.16±6.73)分,均较对照组高(P<0.05)。结论泼尼松与丙硫氧嘧啶联合用药对甲状腺功能亢进症的治疗效果良好,可有效改善患者的甲状腺功能,纠正钙磷代谢紊乱,提升患者生活质量,且联合用药对患者肝肾功能无明显损害,用药安全性良好,不良反应少。
Objective To explore the efficacy of prednisone plus propylthiouracil in the treatment of hyperthyroidism.Methods Eighty patients with hyperthyroidism admitted to our hospital from January 2019 to June 2021 were selected as the research objects,and randomly divided into the control group and the observation group with 40 cases in each group according to the random number table method.The control group was treated with propylthiouracil,while the observation group was treated with propylthiouracil combined with prednisone.The total effective rate,calcium and phosphorus metabolism index,serum hormone level,quality of life score,liver and kidney function index and incidence of adverse reactions were compared between the two groups.Results The total effective rates of observation group and control group were 97.50%and 85.00%respectively,and the total effective rate of observation group was higher than that of control group(P<0.05).After treatment,the levels of blood calcium and phosphorus in the observation group were(1.95±0.20)mmol/L and(1.20±0.29)mmol/L respectively,which were lower than those in the control group(P<0.05).After treatment,the parathyroid hormone,free triodothyronine and free thyroxine in the observation group were(230.37±74.92)pg/ml,(12.86±3.57)pmol/L and(17.92±5.73)pmol/L respectively,which were lower than those in the control group(P<0.05),and the thyroid stimulating hormone in the observation group was(2.04±0.55)mU/L,which was higher than that in the control group(P<0.05).After treatment,the scores of physiology,psychology,environment and social relations in the quality of life in the observation group were(85.07±6.29),(84.98±5.97),(84.05±6.48)and(85.16±6.73)respectively,which were higher than those in the control group(P<0.05).Conclusions Prednisone combined with propylthiouracil has a good therapeutic effect on hyperthyroidism,which can effectively improve patients’thyroid function,correct the disorder of calcium and phosphorus metabolism and improve their quality of life.Moreover,the combined use of prednisone causes no obvious damage to patients’liver and kidney functions,and is characterized by good medication safety and few adverse reactions.
作者
陈卓
CHEN Zhuo(The Third Medical Center of Chinese PLA General Hospital,Beijing 100039,China)
出处
《武警医学》
CAS
2022年第4期307-310,共4页
Medical Journal of the Chinese People's Armed Police Force
