摘要
目的探讨GSDMD蛋白在颞叶胶质瘤合并癫痫患者瘤组织中表达及作用。方法纳入颞叶胶质瘤患者手术治疗54例,其中不合并癫痫28例,合并癫痫26例。手术切除瘤组织后,利用免疫组化检测病灶组织中GSDMD、Caspase-4、NLRP3、IL-1β、TNF表达情况。结果颞叶胶质瘤合并癫痫组患者病灶组织GSDMD、Caspase-4、IL-1β、TNF表达明显高于不合并癫痫组(P<0.05或<0.01),NLRP3表达两组间比较无统计学意义。结论GSDMD、Caspase-4、IL-1β、TNF在颞叶胶质瘤相关性癫痫患者病灶组织中高表达,可能与癫痫发病密切相关。
Objective To investigate the expression and role of Gasdermin-D in tumor tissue of temporal lobe glioma patients with epilepsy.Methods 54 patients with temporal glioma were treated surgically,including 28 cases without epilepsy and 26 cases with epilepsy.After surgical removal of tumor tissue,the expression of Gasdermin-D,Caspase-4,NLRP3,IL-1βand TNF in the lesion tissue was detected by immunohistochemistry.Results The expression of Gasdermin-D,Caspase-4,IL-1β,and TNF in the focal tissues of patients with temporal glioma and epilepsy was significantly higher than that without epilepsy(P<0.05 or<0.01),but the expression of NLRP3 was not statistically significant.Conclusion GSDMD,Caspase-4,IL-1βand TNF are highly expressed in the focal tissues of patients with temporal glioma-related epilepsy,which may be closely related to the incidence of epilepsy.
作者
彭琼
黄红星
匡卫平
朱勇
邹叔骋
周彬
卢军
王琴
陈小峰
Peng Qiong;Huang HongXing;Kuang WeiPing(Brain Hospital of Hunan Province,College of Clinical Medicine,Hunan University of Chinese Medicine,Changsha,410007,China)
出处
《立体定向和功能性神经外科杂志》
2020年第3期129-132,共4页
Chinese Journal of Stereotactic and Functional Neurosurgery
基金
湖南省自然科学基金项目(编号:2019JJ80024、2019JJ80027)
湖南省创新引导计划项目(编号:2018SK50605)
湖南省卫生计生委科研课题(编号:B2019047、20180097)
湖南省脑科医院院级课题(编号:2017B01)
