摘要
目的:探索肾阴虚证客观诊断指标。方法:运用病证结合的方法,选择临床慢性肾炎肾阴虚证的患者为研究对象,设立慢性肾炎肾阳虚证患者组及健康人组进行对照,检测其血清细胞因子IL-1β、IL-2、血清N末端-B型钠尿肽前体(NT-proBNP)的含量。结果:慢性肾炎肾阴虚证患者血清白细胞介素-1β明显高于正常人及慢性肾炎肾阳虚证患者(P<O.01)。慢性肾炎肾阳虚证和肾阴虚证患者血清白细胞介素-2都明显低于正常人(P<O.05),慢性肾炎肾阴虚证和肾阳虚证患者之间无差异(P>0.05)。慢性肾炎肾阴虚证患者NT-proBNP水平显著高于慢性肾炎肾阳虚组、正常对照组患者(P<O.05)。结论:血清白细胞介素-1β和血清N末端-B型钠尿肽前体(NT-proBNP)升高可作为慢性肾炎肾阴虚证的客观诊断指标或者重要参考指标。
objective:to explore the objective diagnostic index of kidney Yin deficiency syndrome.Methods:using the method of combination of disease and syndrome,the selection of clinical chronic nephritis kidney Yin deficiency syndrome patients as the research object,chronic nephritis kidney Yang deficiency syndrome patients group and healthy control group,detect the serum cytokine IL-1β、il-2,serum n-terminal-B type natriuretic peptide precursor(NT-pro BNP)content.Results:serum cytokine il-1βin patients with chronic nephritis and kidney Yin deficiency syndrome was significantly higher than that in normal people and patients with chronic nephritis and kidney Yang deficiency syndrome(P<0.01).Serum cytokine il-2 was significantly lower in patients with chronic nephritis with kidney Yang deficiency and kidney Yin deficiency than that in normal people(P<0.05).There was no difference between patients with chronic nephritis(P>0.05).The level of NT-pro BNP in patients with chronic nephritis and kidney Yin deficiency was significantly higher than that in patients with chronic nephritis and kidney Yang deficiency and normal control group(P<0.05).Conclusion:the changes of some cytokine indexes are relatively elevated,which can be used as part or important reference for the objective diagnosis of chronic nephritis with kidney Yin deficiency syndrome.
基金
河北省省级医学科学研究重点计划项目,批准文号20151020.
