摘要
目的观察山莨菪碱联合糖皮质激素预防小儿肠套叠整复后早期复发的临床疗效。方法回顾性分析我院2017年1月~2019年6月经B超引导下水灌肠首次复位成功的彩超示回盲套型肠套叠416例患儿的临床资料,按整复成功后用药不同分为对照组和实验组,各208例,对照组仅给予禁饮食、补液治疗,实验组在此基础上给予山莨菪碱(静脉滴注,0.6mg·kg-1·24h-1,分3次应用),地塞米松(静脉滴注,每次0.3mg/kg,单次应用),分别观察整复成功后24h,36h,48h及72h内复发情况。结果实验组患儿在整复成功后24h,36h,48h及72h内复发率均明显低于对照组,差异有显著性(P<0.05)。结论山莨菪碱联合糖皮质激素应用于预防小儿肠套叠整复后早期复发的治疗,能够明显降低整复后的复发概率,具有临床推广价值。
Objective To compare and analyze the therapeutic effect of anisodamine combined with glucocorticoids in preventing early recurrence of primary intussusception in children.Methods The clinical data of 416 children with ileocele-type intussusception and successful reset in our hospital from January 2017 to June 2019,were retrospectively analyzed and divided into control group(n=208)and experimental group(n=208)according to different medication.The control group was treated with diet ban and fluid supplementation,the experimental group was given anisodamine(intravenous infusion,0.6mg·kg-1·24h-1,for 3 times)combined with dexamethasone(intravenous infusion,0.3mg/kg each time,single application).The recurrence rate was observed and recorded within 24,36,48 and 72 hours after successful restoration.Results The recurrence rate in the experimental group were significantly lower(P<0.05)than the control group within 24,36,48 and 72hours after successful restoration.Conclusion Anisodamine combined with glucocorticoids can be used in children after successful reset intussusception,which can significantly reduce the recurrence rate and has clinical promotion value.
作者
李军
寇克剑
周健
LI Jun;KOU Kejian;ZHOU Jian(Department of Surgery,Weifang Medical University,Weifang 261053,China;Department of General Surgery,the People's Hospital of Jimo;Department of Pediatric Surgery,Weifang People's Hospital)
出处
《潍坊医学院学报》
2020年第1期35-37,共3页
Acta Academiae Medicinae Weifang
关键词
山莨菪碱
糖皮质激素
肠套叠
早期复发
Anisodamine
Glucocorticoid
Early recurrent intussusception
