摘要
目的通过对明钼菊三合疗法治疗干眼症状与相关眼表指标的观察,旨在了解明钼菊三合疗法治疗干眼的临床疗效与安全性。方法前瞻性选取就诊并完成复诊的干眼患者60例,随机表单盲法分为观察组与对照组。其中30例患者为观察组,采用明钼菊三合疗法联合0.1%玻璃酸钠滴眼液治疗;30例患者为对照组,采用0.1%玻璃酸钠滴眼液治疗。观察治疗前后患者泪膜破裂时间(BUT)、角膜荧光染色评分(FL)及泪液分泌试验(SIT)和症状的变化。结果治愈率观察组为36.67%(11/30),对照组为13.33%(4/30);好转率观察组为43.33%(13/30),对照组为26.67%(8/30);总有效率观察组为80%(24/30),对照组为40%(12/30),差异有统计学意义(P<0.05)。治疗后2组BUT、FL、SIT比较,差异均有统计学意义(P<0.01),且观察组优于对照组。结论明钼菊三合疗法对干眼疗效确切、安全。
Objective To evaluate the efficacy and safety of the triple therapy-molybdenum of chrysanthemum in treating dry eyes,and compare it with the conventional methods.Methods Prospective study,a total of60 age and gender matched subjects with dry eye were divided into 2 groups,30 subjects in the study group and 30 in the control group.The study group of 30 patients were given the triple therapy-molybdenum of chrysanthemum,and associated with Sodium Hyaluronate Eye Drops(0.1%),the control group was 30 patients which given Sodium Hyaluronate Eye Drops(0.1%).The absolute and the relative measurements of the anterior ocular surface,break-up time(BUT),corneal fluorescent staining scores(FL)and Schirmer I test(SIT)were analyzed in pre and post treatments in both groups.Results The cure rate of the observation group was 36.67%(11/30)and the control group was 13.33%(4/30).The improvement rate of the observation group was 43.33%(13/30),the control group was 26.67%(8/30).The total effective treatment group was 80%(24/30),and the control group was 40%(12/30),the difference between the two groups was statistically significant(P<0.05).After treatment,there were significant differences in BUT,SIT and FL between the two groups(P<0.01),and the observation group was better than the control group.Conclusions The findings demonstrate the significant effect and safety of the triple therapy-molybdenum of chrysanthemum in treating dry eyes.
作者
王雅东
李芳兰
马金瑞
律鹏
Wang Ya-dong;Li Fang-lan;Ma Jin-rui;LüPeng(Ophthalmology Department,The Second Hospital of Lanzhou University,Lanzhou 730030,China)
出处
《兰州大学学报（医学版）》
CAS
2018年第4期58-61,共4页
Journal of Lanzhou University（Medical Sciences）
关键词
明钼菊三合疗法
干眼
疗效
triple therapy-molybdenum of chrysanthemum
dry eye
efficacy
