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益气养阴法治疗特发性肺间质纤维化疗效Meta分析 被引量:11

Meta-analysis of the Curative Effect of Qi and Yin-tonifying Therapy for Idiopathic Pulmonary Fibrosis
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摘要 目的系统评价益气养阴法治疗特发性肺间质纤维化的临床有效性。方法通过计算机检索CNKI、万方、维普、PubMed等数据库,时限从建库以来至2019年4月,查找以益气养阴法治疗特发性肺间质纤维化的临床随机对照试验(RCT),对纳入文献进行质量评价后,应用Review Manager 5.3(RevMan 5.3)软件进行Meta分析。结果最终纳入8项RCT,包括524例患者。Meta分析结果显示:益气养阴法治疗特发性肺间质纤维化与对照组对比在临床总有效率方面有明显差异性,OR=3.11,95%CI(2.07,4.66),该差异具有统计学意义(P<0.00001);益气养阴法治疗提高6 min步行距离[MD=38.26,95%CI(14.54,61.98)]、肺功能FEV1/预计值(%)[MD=5.25,95%CI(1.08,9.42)]、肺功能一氧化碳弥散量(DLCO%)[MD=4.75,95%CI(0.73,8.77)];益气养阴法治疗改善气喘[MD=-1.40,95%CI(-1.68,-1.12)]、咳嗽[MD=-1.36,95%CI(-1.83,-0.88)]、乏力[MD=-1.22,95%CI(-1.69,-0.75)]等中医症状,8项RCT有6项提及不良反应,试验组仅有1例不良反应。结论益气养阴法治疗特发性肺间质纤维化的疗效明显优于对照组,且不良反应较小。但由于纳入文献局限性较强,该系统评价结果也存在相应局限性,故需用更多高质量的RCT进一步深入研究益气养阴法治疗特发性肺间质纤维化的有效性。 Objective To systematically evaluate the clinical effectiveness of Qi and Yin-tonifying in the treatment of idiopathic pulmonary fibrosis.Methods CNKI,WanFang,VIP,and PubMed databases were retrieved by computer.Clinical randomized controlled trials(RCT)for the treatment of idiopathic pulmonary fibrosis with Qi and Yin-tonifying were selected from the time of database construction to April 2019.After quality evaluation of the included literatures,Meta-analysis was performed using Review Manager 5.3(RevMan 5.3)software.Results Eight RCTs were eventually included,for a total of 524 patients.The results of meta-analysis showed that there was a significant difference in the total clinical effective rate between the Qi and Yin-tonifying treatment of idiopathic pulmonary fibrosis and the control group,OR=3.11,95%CI(2.07,4.66),the difference being significant(P<0.00001);Qi and Yin-tonifying treatment increased 6-minute walking distance[MD=38.26,95%CI(14.54,61.98)],pulmonary function FEV1/expected value(%)[MD=5.25,95%CI(1.08,9.42)],lung function carbon monoxide diffusion(DLCO%)[MD=4.75,95%CI(0.73,8.77)];Qi and Yin-tonifying treatment can improve asthma[MD=-1.40,95%CI(-1.68,-1.12)],cough[MD=-1.36,95%CI(-1.83,-0.88)],fatigue[MD=-1.22,95%CI(-1.69,-0.75)]and other TCM symptoms.Six of the eight RCTs mentioned adverse reactions,and only one adverse reaction occurred in the experimental group.Conclusion The efficacy of Qi and Yin-tonifying treatment of idiopathic pulmonary fibrosis is significantly better than that in the control group,and has less adverse reactions.However,due to the limitations of the included literature,the evaluation results of this meta-analysis also have corresponding limitations.Therefore,more high-quality RCT is needed to further study the effectiveness of Qi and Yin-tonifying treatment of idiopathic pulmonary fibrosis.
作者 张馨心 吕晓东 庞立健 臧凝子 邓岳潼 ZHANG Xinxin;LYU Xiaodong;PANG Lijian;ZANG Ningzi;DENG Yuetong(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China;The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China)
出处 《辽宁中医药大学学报》 CAS 2020年第2期96-100,共2页 Journal of Liaoning University of Traditional Chinese Medicine
基金 辽宁省“兴辽英才计划”高水平创新团队项目(XLYC1808011) 国家自然科学基金面上项目(81373579) 国家自然科学基金青年基金(81403290) “十二五”国家中医药管理局中医络病重点学科建设项目(2012020108-202).
关键词 特发性肺纤维化 益气养阴法 临床随机对照试验 Meta分析 idiopathic pulmonary fibrosis Qi and Yin-tonifying treatment clinical randomized controlled trials Meta-analysis
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