摘要
生酮饮食是一种高脂、低碳水化合物的饮食,1920年,生酮饮食开始被用来治疗癫痫,尤其作为耐药性癫痫的一种非药物治疗方式,尽管生酮饮食是安全、有效的,仍需关注其对骨骼生长带来的不利影响。生酮饮食导致骨质疏松症的最早临床报道见于1979年,在治疗难治性癫痫时患者出现了显著的骨矿物质丢失,近年来,基础研究提示生酮饮食能够导致实验小鼠松质骨以及皮质骨骨量的减少,提示在应用生酮饮食治疗的过程中应该辅助应用一些促成骨类药物,研究表明中药及其有效成分促成骨效能明确,课题组前期的研究表明中药能够正向调节骨代谢,因此有必要对生酮饮食负向调节骨代谢的研究进展做一详尽的综述,以期用传统中药干预,弘扬祖国医学的潜在优势。
Ketogenic diet(KD)is described as a high-fat and low-carbohydrate diet,KD was initially used in 1920s for the treatment of epilepsy and especially validated as an effective non-pharmacological preventive treatment for drug-resistant epilepsy.Although KD was reported as a safe and effective treatment,its adverse reactions and impact on bone growth and development had been drawn attention,KD-associated osteoporosis was reported in clinic firstly in 1979,cliniciansfound progressive loss of bone mineral content in patients withintractable epilepsy,besides,recent studies indicated that KD compromises both cancellous and cortical bone mass in mice,it is sensible to supply osteogenic drugs with the KD treatment.Researches have shown that traditional chinese medicine and its active ingredients can significantly promote osteogenesis,moreover,our previous studies showed that chinese medicine can positively regulate bone metabolism,so it isnecessary to review the research progress of KD negatively regulate bone metabolism in order to intervened with traditional chinese medicine andpromote the potential advantages of traditional chinese medicine.
作者
姜涛
邵敏
黄永青
陈庆真
杨冰璇
欧阳艳菲
JIANG Tao;SHAO Min;HUANG Yongqing;CHEN Qingzhen;YANG Bingxuan;OUYANG Yanfei(The Third Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510240,Guangdong,China)
出处
《辽宁中医药大学学报》
CAS
2020年第1期128-131,共4页
Journal of Liaoning University of Traditional Chinese Medicine
基金
国家自然科学基金面上项目(81373654)
广东省自然科学基金(2015A030313351)
广东省科技计划(2014A020221052)
广东省中医药局项目(20164010)
广州市科技计划(201707010463).
关键词
生酮饮食
骨代谢
高脂饮食
中医药
ketogenic diet
bone metabolism
high-fat diet
chinese medicine
