摘要
目的探究化痰通腑汤加减治疗缺血性中风的疗效及对血浆血管紧张素Ⅱ(AngⅡ)、脂蛋白相关磷脂酶A2(LP-PLA2)、泛素羧基末端水解酶-1(UCH-L1)水平的影响。方法选择哈尔滨市中医医院2019年1月—2021年1月收治的120例缺血性中风患者,使用随机数字表将其分为参照组和治疗组,各纳入60例,比较两组临床疗效、AngⅡ、LP-PLA2、UCH-L1、炎症因子、Barthel指数和国立卫生研究院卒中量表(NIHSS)评分。结果两组患者临床疗效等级差异有统计学意义(P<0.05),治疗组有效率高于参照组(P<0.05),差异具有统计学意义。两组患者治疗前血浆AngⅡ、LP-PLA2、UCH-L1水平差异无统计学意义(P>0.05),两组患者治疗后血浆AngⅡ、LP-PLA2、UCH-L1水平均显著降低(P<0.05),且治疗组血浆AngⅡ、LP-PLA2、UCH-L1水平低于参照组(P<0.05),差异有统计学意义。两组患者治疗前超敏C反应蛋白(hs-CRP)、肿瘤坏死因子(TNF-α)、白细胞介素-18(IL-18)差异无统计学意义(P>0.05),两组患者治疗后hs-CRP、TNF-α、IL-18均显著减少(P<0.05),且治疗组hs-CRP、TNF-α、IL-18少于参照组(P<0.05),差异有统计学意义。两组患者治疗前Barthel指数和NIHSS评分差异无统计学意义(P>0.05),两组患者治疗后Barthel指数升高(P<0.05),NIHSS评分降低(P<0.05),且治疗组Barthel指数高于参照组(P<0.05),NIHSS评分低于参照组(P<0.05),差异有统计学意义。结论化痰通腑汤治疗缺血性中风患者成效显著,可以降低患者AngⅡ、LP-PLA2、UCH-L1水平,改善患者炎症反应和神经损伤,提高患者生活活动能力,临床值得应用。
Objective To explore the curative effect of Modified Huatan Tongfu Decoction(化痰通腑汤加减)in the treatment of ischemic stroke,and its influence on levels of plasma angiotensinⅡ(AngⅡ),lipoprotein associated phospholipase A2(LP-PLA2)and ubiquitin carboxy-terminal hydrolase-1(UCH-L1).Methods A total of 120 patients with ischemic stroke admitted to Heilongjiang Provincial Hospital of Traditional Chinese Medicine were selected between January 2019 and January 2021.They were divided into reference group and treatment group using random number table method,with 60 cases in each group.Patients in the reference group were treated with conventional western medicine,and those in the treatment group were treated with Modified Huatan Tongfu Decoction on this basis.Clinical effects,levels of Ang II,LP-PLA2,UCH-L1 and inflammatory factors,the Barthel index and the National Institutes of Health Stroke Scale(NIHSS)scores were compared between the two groups.Results The clinical response rate in the treatment group was higher than that in the reference group(P<0.05).There was no significant difference in levels of plasma AngⅡ,LP-PLA2 and UCH-L1 between the two groups before treatment(P>0.05).After treatment,the levels of the three indicators were significantly reduced in the two groups(P<0.05)and lower in the treatment group than those in the reference group(P<0.05).There was no significant difference in high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor(TNF-α)or interleukin-18(IL-18)between the two groups before treatment(P>0.05).After treatment,the inflammatory factors were significantly reduced in the two groups(P<0.05)and lower in the treatment group than those in the reference group(P<0.05).There was no significant difference in Barthel index or NIHSS scores between the two groups before treatment(P>0.05).After treatment,the Barthel index was increased and the NIHSS scores were reduced in the two groups(P<0.05).Meanwhile,the treatment group had higher Barthel index score and lower NIHSS scores than the reference group(P<0.05).Conclusion Modified Huatan Tongfu Decoction is effective in the treatment of patients with ischemic stroke,which can reduce the levels of AngⅡ,LP-PLA2 and UCH-L1,alleviate the inflammatory response and nerve damage and improve the activities of daily living of the patients.
作者
宋聪琳
杨金山
SONG Conglin;YANG Jinshan(Harbin Hospital of Traditional Chinese Medicine,Harbin 150076,Heilongjiang,China)
出处
《辽宁中医杂志》
CAS
2022年第6期80-83,共4页
Liaoning Journal of Traditional Chinese Medicine
关键词
缺血性中风
化痰通腑汤
疗效
血管紧张素Ⅱ
脂蛋白相关磷脂酶A2
泛素羧基末端水解酶-1
ischemic stroke
Huatan Tongfu Decoction(化痰通腑汤)
curative effect
angiotensinⅡ
lipoprotein-associated phospholipase A2
ubiquitin carboxy-terminal hydrolase-1
