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独活寄生汤加味治疗骨质疏松症疗效观察 被引量:2

Curative Effect of Modified Duhuo Jisheng Decoction(独活寄生汤加味)in Treatment of Osteoporosis
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摘要 目的研究并观察独活寄生汤加味治疗骨质疏松症(osteoporosis,OP)对患者骨密度及血清胰岛素样生长因子-1(IGF-1)、胰岛素样生长因子结合蛋白-3(IGFBP-3)水平的影响。方法选择2018年3月—2020年9月于该院就诊的106例OP患者,按随机数表法分为观察组和对照组,各53例。对照组接受常规药物治疗,观察组同时服用独活寄生汤加味治疗。观察两组临床疗效、中医证候评分变化、骨密度测量结果、骨代谢指标[骨钙素(OC)、Ⅰ型前胶原氨基端肽(PⅠNP)、Ⅰ型胶原交联C-末端肽(CTX)]水平、血清IGF-1、IGFBP-3水平变化及药物不良反应。结果治疗后,观察组临床总有效率为96.23%(51/53),高于对照组83.02%(44/53)(P<0.05);观察组各项中医证候评分均低于对照组(P<0.05);观察组股骨颈、腰椎L、Ward′s三角区骨密度高于对照组(P<0.05);观察组OC水平高于对照组,PⅠNP、CTX水平低于对照组(P<0.05);观察组IGF-1、IGFBP-3水平高于对照组(P<0.05);两组均无不良反应发生。结论独活寄生汤加味结合常规方案可有效治疗OP、缓解患者症状,可通过调节骨代谢和IGF-1、IGFBP-3等因子水平提升骨密度,药物安全性好。 Objective To study and observe the effects of Modified Duhuo Jisheng Decoction(独活寄生汤加味)on bone mineral density,serum levels of insulin-like growth factor-1(IGF-1)and insulin-like growth factor binding protein-3(IGFBP-3)in patients with osteoporosis(OP).Methods A total of 106 OP patients treated in the hospital from March 2018 to September 2020 were enrolled and divided into the observation group and the control group according to random number table method,53 cases in each group.The control group was treated with routine drugs,while the observation group was additionally treated with Modified Duhuo Jisheng Decoction.The clinical curative effect,changes in scores of TCM syndromes,measurement results of bone mineral density,changes in levels of bone metabolism indexes[osteocalcin(OC),procollagen I N-terminal peptide(PINP),collagen cross-linking C-terminal peptide(CTX)],serum IGF-1 and IGFBP-3 and adverse drug reactions in both groups were observed.Results After treatment,the total clinical response rate of the observation group was higher than that of the control group[96.23%(51/53)vs 83.02%(44/53)](P<0.05).The scores of TCM symptoms in the observation group were lower than those in the control group(P<0.05).The bone mineral density of femoral neck,lumbar L1-4 and Ward′s trigonum were higher than those in the control group(P<0.05).The OC level was higher than that in the control group.The levels of PINP and CTX were lower than those in the control group(P<0.05),and the levels of IGF-1 and IGFBP-3 were higher than those in the control group(P<0.05).There were no adverse reactions in two groups.Conclusion Modified Duhuo Jisheng Decoction combined with routine regimens can effectively treat OP and relieve the symptoms in patients.It can increase the bone mineral density by regulating the bone metabolism and the levels of factors such as IGF-1 and IGFBP-3,with good safety.
作者 王传珍 滕军燕 赵振江 吴丹 苏晓川 晋果果 WANG Chuanzhen;TENG Junyan;ZHAO Zhenjiang;WU Dan;SU Xiaochuan;JIN Guoguo(Luoyang Orthopedic Hospital of Henan Province,Zhengzhou 450000,Henan,China)
出处 《辽宁中医杂志》 CAS 2022年第5期115-119,共5页 Liaoning Journal of Traditional Chinese Medicine
基金 河南省中医药科学研究专项课题(2018ZYZD03)
关键词 独活寄生汤加味 骨质疏松症 骨密度 胰岛素样生长因子-1 胰岛素样生长因子结合蛋白-3 Modified Duhuo Jisheng Decoction(独活寄生汤加味) osteoporosis bone mineral density insulin-like growth factor-1 insulin-like growth factor binding protein-3
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