摘要
目的观察中药补肾调周序贯疗法治疗多囊卵巢综合征(PCOS)的临床疗效。方法53例患者口服补肾调周中药,每日1剂,连服6个月,或服至确认妊娠。观察患者治疗前后月经周期、性激素水平[促黄体生成素(LH)、促卵泡生成素(FSH)、雌二醇(E_(2))、睾酮(T)、催乳素(PRL)]、卵巢大小变化情况,及治疗6个月内的妊娠率。结果6个月内,妊娠率为23.8%(10/42)。治疗6个月后,43例未妊娠的患者T、LH及LH/FSH明显下降,月经周期缩短,双卵巢体积减小(P<0.01),差异均有统计学意义;FSH、E_(2)及PRL治疗前后差异无统计学意义。结论中药补肾调周序贯疗法能调节PCOS患者月经周期,降低其T、LH、LH/FSH水平,缩小卵巢体积,改善临床妊娠率,值得推广。
Objective To observe clinical effects of sequential therapy of tonifying kidney and regulating menstruation in the treatment of polycystic ovary syndrome(PCOS).Methods Fifty-three patients took the traditional Chinese medicine for tonifying the kidney and regulating the menstrual cycle orally with 1 dose per day for 6 months,or took the medicine until pregnancy was confirmed.The levels of sex hormones(LH,FSH,E_(2),T,PRL)were measured before and after treatment,and the menstrual cycles before and after treatment were recorded.The changes of ovarian size were examined by ultrasound,and the pregnancy rate within 6 months after treatment was calculated.Results Within 6 months,10 patients with planned pregnancy were confirmed to be pregnant and the pregnant rate was 23.8%(10/42).After 6 months of treatment,while levels of T,LH and LH/FSH were decreased significantly in the non-pregnant patients.The menstrual cycle shortened,and the volume of double ovaries decreased significantly after 6 months of treatment(P<0.01).The levels of FSH,E_(2)and PRL had no significance before and after treatment.Conclusion The sequential therapy of tonifying kidney can significantly improve the levels of related hormones in PCOS patients and increase the pregnancy rate,which is worthy of clinical promotion.
作者
易莎
刘艳霞
王阳
邢雅雯
仰艳
肖慧
征征
杜贞苹
邢玉
YI Sha;LIU Yanxia;WANG Yang;XING Yawen;YANG Yan;XIAO Hui;ZHENG Zheng;DU Zhenping;XING Yu(Beijing University of Chinese Medicine,Beijing 100029,China;Dongfang Hospital,Beijing University of Chinese Medicine,Beijing 100078,China)
出处
《辽宁中医杂志》
CAS
2022年第2期68-71,共4页
Liaoning Journal of Traditional Chinese Medicine
基金
国家自然科学基金青年基金(81904241)
关键词
多囊卵巢综合征
中药序贯疗法
补肾调周
雄激素
月经周期
妊娠率
polycystic ovary syndrome
sequential traditional Chinese medicine therapy
tonifying kidney and regulating menstruation
testosterone
menstrual cycle
pregnancy rate
