摘要
目的探讨益气滋肾扶正法联合生物反应调节剂对肾癌根治性切除术后免疫功能与生存质量的影响。方法筛选92例2018年9月—2019年12月于该院接受肾癌根治切除术的患者,依据随机对照法,随机分为治疗组及对照组,各46例,对照组予单纯生物反应调节剂治疗,治疗组予益气滋肾扶正法联合生物反应调节剂进行治疗,疗程为3个月。观察两组患者中医症状积分改变情况,治疗前后患者免疫细胞因子(CD_(3)^(+)、CD_(4)^(+)、CD_(8)^(+)、CD_(4)^(+)/CD_(8)^(+))及生存质量EORTC QLQ-C30评分改善情况,并比较两组临床疗效及不良反应。结果治疗后,两组患者腰膝酸软、口干咽燥、乏力倦怠等症状均有改善,症状积分均明显降低(P<0.05),且组间比较,治疗组降低更明显(P<0.05);两组患者CD_(3)^(+)、CD_(4)^(+)、CD_(4)^(+)/CD_(8)^(+)均明显升高,且治疗组升高更明显(P<0.05);CD_(8)^(+)均明显降低,且较对照组相比,治疗组降低幅度更大(P<0.05);治疗后,两组患者EORTC QLQ-C30评分中认知、社会、角色、躯体、情绪功能均较治疗前有明显升高(P<0.05),且除认知功能外,其余功能治疗组评分均升高更显著(P<0.05);治疗组的临床疗效优于对照组[89.13%(41/46),73.91%(34/46)](P<0.05);治疗组较对照组不良反应发生率更低[8.7%(4/46),23.9%(11/46)],差异具有统计学意义(P<0.05)。结论针对肾癌根治性切除术后患者,使用益气滋肾扶正法联合生物反应调节剂,安全有效,可显著提高患者免疫功能,改善生存质量,临床值得应用。
Objective The purpose of this paper was to discuss the effect of Yiqi Zishen Fuzheng method combined with BRM on immune function and life-quality of RCC patients after radical nephrectomy.Methods The information of RCC patients after radical nephrectomy who admitted to our hospital from September 2018 to December 2019 was collected.According to the random control method,92 patients were randomly divided into control group(group A)and treatment group(group B).Forty-six patients in the group A were treated with simple biological response modifier(BRM)treatment.The other forty-six patients in the group B were treated with Yiqi Zishen Fuzheng method combined with the treatment in the group A.The treatment course was 3 months.TCM symptom score changes,immune cytokine levels(includingCD_(3)^(+)、CD_(4)^(+)、CD_(8)^(+)、CD_(4)^(+)/CD_(8)^(+)),improvements of EORTC QLQ-C30 scores,clinical efficacy,and adverse reactions of the two groups were compared.Results After treatment,symptoms such as lumbar debility,dry mouth and throat,fatigue and burnout were improved in both groups,and the syndrome scores were significantly reduced(P<0.05).The decrease of group B was more obvious(P<0.05).Most of the immune cytokines levels in both groups were increased significantly,especially those in group B(P<0.05).The CD_(8)^(+) level of patients in both groups was decreased significantly,and the decrease in group B was greater than that of group A.As far as EORTC QLQ-C30 score was concerned,the scores of cognitive,social,role,body and emotional function modules in both groups were obviously higher than those before treatment(P<0.05).The scores of patients in group B were significantly higher than those in group A in all modules except for the cognitive function(P<0.05).The clinical total effective rate of group B(89.13%,41/46)was superior to that of group A(73.91%,34/46).The incidence of adverse reactions of group A(23.9%,11/46)was higher than that of group B(8.7%,4/46)(P<0.05).Conclusion For RCC patients after radical nephrectomy,Yiqi Zishen Fuzheng method combined with BRM is safe and effective,which can significantly improve patients′immune function and life-quality,and is worthy of clinical application.
作者
于垂恭
韩涛
YU Chuigong;HAN Tao(The Third Medical Center of PLA General Hospital,Beijing 100039,China;Affiliated Hospita of China Medical University,Shenyang 116023,Liaoning,China;The Theory And Application of Traditional Chinese Medicine Visceral Manifestations Key Laboratory of The State Ministry of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China)
出处
《辽宁中医杂志》
CAS
2021年第12期112-115,共4页
Liaoning Journal of Traditional Chinese Medicine
基金
国家自然科学基金面上项目(81372329)
国家自然科学基金青年基金(81702622)
中国博士后科学基金特别资助项目(2017T100827)
辽宁省自然科学基金(2018011151)
辽宁中医药大学中医脏象理论及应用国家教育部重点实验室开放基金(zyzx1710)
