摘要
目的探讨丹红注射液对急性心肌梗死(AMI)患者急诊PCI术后心肌再灌注损伤的疗效。方法选取2018年1月—2019年1月于该院治疗的AMI行急诊PCI术的患者100例,随机分为治疗组和对照组,两组患者均行急诊PCI手术治疗,均给予抗血小板聚集、抗凝、稳定斑块等常规药物治疗,治疗组在常规治疗基础上加用丹红注射液静点(用法为丹红注射液40 mg加入5%葡萄糖注射液或0.9%氯化钠注射液250 mL中稀释后静点),治疗14 d为1个疗程。观察比较两组患者治疗后心律失常发生率、心绞痛再发率、院内心力衰竭发生率,对比两组患者肌钙蛋白I(cTnT)、肌酸激酶同工酶(CK-MB)、N-末端B型脑钠肽(NT-proBNP)及高敏C反应蛋白(hs-cRP)的水平变化、心电图ST段回落情况及药物不良反应。结果治疗组患者术后再灌注心律失常、心绞痛、心力衰竭发生率显著低于对照组,组间比较差异有统计学意义(P<0.05)。治疗组患者治疗后血清cTnT、CK-MB峰值显著低于对照组,差异有统计学意义(P<0.05),治疗组NT-proBNP、hs-CRP低于对照组,差异有统计学意义(P<0.05),心电图ST段回落>70%比例治疗组高于对照组,差异有统计学意义(P<0.05),丹红治疗组无药物不良反应发生。结论AMI患者经急诊PCI及丹红注射液治疗,可有效减少再灌注心律失常、梗死后心绞痛、心力衰竭发生,降低血清心肌酶、NT-proBNP、hs-CRP水平,对心肌具有保护作用。
Objective To investigate the effect of Danhong Injection on myocardial reperfusion injury after emergency PCI in patients with acute myocardial infarction(AMI).Methods A hundred cases of AMI patients admitted to our department for emergency PCI between January 2018 and January 2019 were selected and randomly divided into treatment group and control group.Emergency PCI was performed in both groups.All patients were treated with conventional drugs such as anti-platelet aggregation,anti-coagulation and antiatherosclerosis.In the treatment group,Danhong Injection was added on the basis of conventional treatment.Fourteen days was a course of treatment.We observed and compared the incidence of arrhythmia,angina recurrence rate,and the incidence of hospital heart failure after treatment in the two groups of patients,and compared the levels of troponin I(cTnT),creatine kinase isoenzyme(CK-MB),n-terminal b-type brain natriuretic peptide(NT-proBNP)and high-sensitive C-reactive protein(hs-CRP),the ST segment of electrocardiogram and adverse drug reactions in the two groups of patients.Results The incidence of arrhythmia,angina and heart failure after perfusion in the treatment group was significantly lower than that in the control group(P<0.05).After treatment,the peak values of serum cTnT and CK-MB of patients in the treatment group were significantly lower than those in the control group,and the difference was statistically significant(P<0.05).In the treatment group,NT-proBNP,hs-CRP were lower than those in the control group,and the difference was statistically significant(P<0.05).Conclusion Emergency PCI and Danhong Injection can effectively reduce the occurrence of reperfusion arrhythmia,post-infarction angina and heart failure in AMI patients,reduce the levels of serum myocardial enzyme,NT-proBNP and hs-CRP,and have a protective effect on myocardium.
作者
吕涛
LYU Tao(Cardiology Department,Affiliated Hospital of Chifeng College,Chifeng 024000,Inner Mongolia,China)
出处
《辽宁中医杂志》
CAS
2020年第8期118-120,共3页
Liaoning Journal of Traditional Chinese Medicine
关键词
急性心肌梗死
急诊PCI丹红注射液
心肌再灌注损伤
acute myocardial infarction
emergency PCI
Danhong Injection
myocardial reperfusion injury
