摘要
肌萎缩侧索硬化(ALS)是一种致命的神经退行性疾病,病理特征表现为上下运动神经元进行性丢失,ALS病因和病理生理学机制尚不清楚,治疗措施少且疗效有限。因此,寻找病因并开发新的干预措施,以期缓解ALS患者疾病进展成为临床医生的迫切需要。最新研究表明,肠道微生物群对人类健康和疾病起着关键作用,并通过“肠-脑轴”与中枢神经系统产生联系,肠道微生物群可能与ALS的病因和进展有关。文中查阅国内外文献,将肠道微生物群与ALS的相关性研究最新进展作综述。
Amyotrophic lateral sclerosis(ALS)is a fatal neurodegenerative disease,which is characterized by progressive loss of upper and lower motor neurons.The etiology and pathophysiological mechanisms of the disease are still unclear.There are few treatments and limited efficacy.It is urgent to find the cause and develop new interventions to alleviate the disease progression.Recent research shows that the intestinal microbiomes plays a key role in human health and disease,and is connected with the central nervous system through the gut-brain axis.The intestinal microbiomes may be related to the etiology and progress of ALS.The research progress on the correlation between intestinal microbiomes and amyotrophic lateral sclerosis were reviewed.
作者
徐胜媛
王薇
徐仁伵
XU Sheng-yuan;WANG Wei;XU Ren-shi(Department of Cerebrocascular Disease,Beijing Anzhen Hospital Affiliated to Capital Medical University,Beijing 100029,China;Department of Neurology,Jiangxi Provincial People’s Hospital,Nanchang 330006,China)
出处
《中国临床神经科学》
2023年第3期355-359,365,共6页
Chinese Journal of Clinical Neurosciences
基金
国家自然基金面上项目(编号:30560042,81160161,81360198)
关键词
肠道微生物群
肌萎缩侧索硬化
肠-脑轴
intestinal microbiomes
amyotrophic lateral sclerosis
gut-brain axis
