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海南省碘营养状况和甲状腺疾病的调查分析 被引量:1

Investigation and analysis of iodine nutritional status and thyroid diseases in Hainan province
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摘要 目的探讨海南省碘营养状况和甲状腺疾病的发病情况。方法于2018~2020年在海南省19个市县中随机选择符合纳入标准的受试者填写调查问卷,检测其中段尿尿碘浓度(UIC)、血促甲状腺激素(TSH)、甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TgAb)水平,并行甲状腺彩超检查。比较不同性别、年龄段受试者的尿碘中位数(MUI)。近3天未进食海带或紫菜受试者中,将碘重度缺乏和碘缺乏者作为U1组,碘适量者作为U2组,碘超适量者作为U3组,碘过量者作为U4组,比较4组及不同性别TPOAb、TgAb阳性、甲状腺结节患者比例。结果共纳入1981例受试者,对其中1699例近3天未进食海带或紫菜受试者进行进一步分析。男性受试者MUI高于女性(P<0.001),40~49岁受试者MUI高于≥70岁受试者(P<0.05)。U1组463例(27.4%),U2组729例(42.9%),U3组349例(20.5%),U4组158例(9.3%)。TSH水平异常192例(11.3%)。U4组TSH升高患者比例高于U2组(P<0.05)。TPOAb阳性343例(20.2%),TgAb阳性320例(18.8%),甲状腺结节676例(39.8%)。U4组TgAb阳性患者比例高于U2组、U3组(P<0.05)。女性TPOAb阳性、TgAb阳性及甲状腺结节患者比例均高于男性(P<0.001)。结论海南省碘营养状态总体处于适宜水平;而女性及老年人更易受缺碘的影响,需要加强碘的补充;碘过量可导致TSH升高及TgAb阳性率增加;因此提倡科学个体化补碘。 Objective To evaluated the iodine nutritional status and incidence of thyroid diseases in Hainan province.Methods From 2018 to 2020,subjects meeting the inclusion criteria were randomly selected from 19 cities and counties in Hainan province and filled in the questionnaire,urine iodine concentration(UIC)of midstream urine,blood thyroid stimulating hormone(TSH),thyroid peroxidase antibody(TPOAb)and thyroglobulin antibody(TgAb)were detected,and thyroid color ultrasound was performed.Median urinary iodine(MUI)of subjects in different gender and ages were compared.Among the subjects who did not eat kelp or laver in the last 3 days,patients with severe iodine deficiency and iodine deficiency were treated as U1 group,patients with moderate iodine was treated as U2 group,patients with excessive iodine was treated as U3 group and patients with iodine excess was treated as U4 group.Rates of patients with TPOAb,TgAb positive and thyroid nodules were compared among the 4 groups and different genders.Results A total of 1981 subjects were included,among which 1699 subjects who did not eat kelp or laver in the last 3 days were further analyzed.MUI of male was higher than that of female(P<0.001),and MUI of subjects aged 40-49 years old was higher than that of≥70 years old(P<0.05).There were 463 cases(27.4%)in U1 group,729 cases(42.9%)in U2 group,349 cases(20.5%)in U3 group and 158 cases(9.3%)in U4 group.There were 192 cases(11.3%)with abnormal TSH level.Rate of patients with elevated TSH in U4 group was higher than that in U2 group(P<0.05).There were 343 cases(20.2%)with TPOAb positive,320 cases(18.8%)with TgAb positive,and 676 cases(39.8%)with thyroid nodules.Rate of patients with TgAb positive in U4 group was higher than those in U2 group and U3 group(P<0.05).Rates of patients with TPOAb positive,TgAb positive and thyroid nodules in females were higher than those in males(P<0.001).Conclusion The iodine nutrition status in Hainan province is generally at an appropriate level.Women and the elderly are more likely to be iodine deficiency and needed to strengthen iodine supplementation.Excessive iodine can increase the rate of elevated TSH and TgAb positive.Therefore,scientific and individual iodine supplement is advocated.
作者 林丹红 方团育 全会标 林璐 陈存仁 林乐韦华 欧倩滢 岑超平 张华川 陈开宁 陈道雄 Lin Danhong;Fang Tuanyu;Quan Huibiao;Lin Lu;Chen Cunren;Lin Leweihua;Ou Qianying;CenChaoping;Zhang Huachuan;Chen Kaining;Chen Daoxiong(Department of Endocrinology,Hainan General Hospital,Haikou 570311,China;不详)
出处 《临床内科杂志》 CAS 2022年第12期814-817,共4页 Journal of Clinical Internal Medicine
基金 海南省重点研发计划社会发展项目(ZDYF2019156) 海南省卫生健康行业科研项目(20A200253)
关键词 碘营养 尿碘 甲状腺过氧化物酶抗体 甲状腺球蛋白抗体 甲状腺结节 Iodine nutrition Urinary iodine Thyroid peroxidase antibody Thyroglobulin antibody Thyroid nodule
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