摘要
目的使用高分辨率磁共振血管壁成像技术定量评估大脑中动脉粥样硬化斑块特征,以提高对其所致临床症状的病理生理机制的认识。方法将2016年6月至2019年3月在新疆医科大学第二附属医院就诊的56例符合纳入及排除标准的大脑中动脉狭窄患者连续纳入本研究,根据NIHSS评分、临床表现以及扩散加权成像上大脑中动脉供血区是否存在高信号,分为症状组和无症状组,其中症状组31例,无症状组25例。所有患者均接受常规MRI及高分辨率磁共振血管壁成像检查,比较两组的临床特征(年龄、性别、吸烟史、高血压史、糖尿病史、高脂血症)及斑块特征(狭窄程度、重构指数、偏心指数、强化程度)。结果症状组及无症状组患者主要临床特征和管腔狭窄程度、重构指数无显著统计学差异(P>0.05),症状组的斑块强化程度及偏心指数相对无症状组更高。结论高分辨率磁共振血管壁成像能够对大脑中动脉粥样硬化狭窄患者的病变程度进行全面的定量评估。并且症状性大脑中动脉粥样硬化斑块具有明显特征。
Objective To evaluate the characteristics of plaques in symptomatic patients with middle cerebral artery atherosclerosis by high-resolution vessel wall magnetic resonance imaging,so as to improve the understanding of the pathophysiological mechanism of clinical symptoms.Methods A total of 56 patients with middle cerebral artery atherosclerotic disease who presented to the Second Affiliated Hospital of Xinjiang Medical University From June 2016 to March 2019,who met the inclusion and exclusion criteria were enrolled in this study.According to the NIHSS score and clinical manifestations,and whether there was high signal in the blood supply area of middle cerebral artery on DWI,they were divided into symptom group and asymptomatic group.Among them,31 patients were enrolled in the symptom group and 25 patients in the asymptomatic group,all patients underwent routine MRI and examined by high-resolution vessel wall magnetic resonance imaging.The clinical characteristics(age,sex,smoking history,hypertension history,diabetes history,hyperlipidemia)and the characteristics of plaque(stenosis degree,eccentricity index,remodeling index,contrast enhancement)were compared between the two groups.Results There was no significant difference in main clinical features,degree of stenosis and remodeling index between symptomatic group and asymptomatic group(P>0.05).The degree of plaque enhancement and eccentricity index in the symptomatic group were higher than those in the asymptomatic group.Conclusion High-resolution vessel wall magnetic resonance imaging can evaluate the degree of middle cerebral artery atherosclerosis comprehensively and the characteristics of symptomatic patients with middle cerebral artery atherosclerosis plaque.
作者
吴静静
贾琳
王云玲
韩秉艳
贾文霄
WU Jingjing;JIA Lin;WANG Yunling(The Second Affiliated Hospital of Xinjiang medical University,Xinjiang Province,Urumqi 830028,P.R.China)
出处
《临床放射学杂志》
CSCD
北大核心
2020年第11期2152-2155,共4页
Journal of Clinical Radiology
基金
国家自然科学基金资助项目(编号:81860301)
自治区科技支疆资助项目(编号:2018E02063)
关键词
高分辨率磁共振血管壁成像
症状性
斑块
High-resolution vessel wall magnetic resonance imaging
Symptomatic
Plaque
