摘要
维生素D(vitamin D,VD)也被称为骨化醇,是一种脂溶性固醇类衍生物,属于类固醇激素。维生素D受体(vitamin D receptor,VDR)是一种亲核蛋白,是介导VD的活性代谢产物1,25(OH)D发挥生物效应的核内生物大分子,在调节机体钙磷代谢、组织细胞损伤修复、氧化应激、炎症反应、免疫系统的调节和其他生物过程中发挥着重要作用。近年来,VDR基因的单核苷酸多态性(single nucleotide polymorphism,SNPs)与疾病之间的关联成为热门话题,本文回顾了VDR基因多态性与常见儿童疾病的相关性,对现有的研究结果作一综述。
Vitamin D(VD),also known as osteopontin,is a fat-soluble steroid derivative and a steroid hormone.Vitamin D receptor(VDR)is a nucleophilic protein,which is a nuclear biological macromolecule that mediates the biological effect of 1,25(OH)D,the active metabolite of VD.It plays an important role in regulating calcium and phosphorus metabolism,tissue and cell damage repair,oxidative stress,inflammatory reaction,immune system regulation and other biological processes.In recent years,the association between single nucleotide polymorphisms(SNPs)of VDR genes and diseases has become a hot topic.In this paper,we review the relevance of VDR gene polymorphisms to common childhood diseases and present a review of the available findings.
作者
高洁
张春霞
GAO Jie;ZHANG Chunxia(Inner Mongolia Medical University,Inner Mongolia Autonomous Region,Hohhot,010050,China;Affiliated Hospital of Inner Mongolia Medical University,Department of Pediatrics,Inner Mongolia Autonomous Region,Hohhot,010050,China)
出处
《疾病监测与控制》
2023年第2期163-168,共6页
Journal of Diseases Monitor and Control
