摘要
目的分析甲胎蛋白(AFP)、癌胚抗原125(CA125)、妊娠相关蛋白A(PAPP-A)、胎盘生长因子(PLGF)四项血清学指标在预测孕妇胎盘早剥中的价值。方法选择2018年9月—2020年11月在周口市疾病预防控制中心专科病医院产检的152例孕妇为研究对象,将疑似胎盘早剥的孕妇分为观察组(n=91),产检健康的孕妇分为对照组(n=61),并根据病理检查结果,将所有孕妇分为胎盘早剥组(n=92)和无胎盘早剥组(n=60),检测所有孕妇的血清AFP、CA125、PAPP-A、PLGF水平,采用受试者工作特征(ROC)曲线下面积(AUC)分析四项血清学指标单独及联合检测预测孕妇胎盘早剥的价值。结果根据病理检查结果,观察组89例孕妇发生胎盘早剥,2例孕妇无胎盘早剥,对照组3例孕妇发生胎盘早剥,58例孕妇无胎盘早剥;随着胎盘早剥分度的增加,AFP、CA125水平呈上升趋势(P<0.05),PAPP-A、PLGF水平呈下降趋势(P<0.05);AFP、CA125、PAPP-A、PLGF单独及联合检测预测孕妇胎盘早剥的AUC值分别为0.670、0.786、0.749、0.763及0.897,四项血清学指标联合检测预测孕妇胎盘早剥的AUC值明显高于单独检测(P<0.05)。结论胎盘早剥孕妇血清PAPP-A、PLGF水平明显降低,而血清AFP、CA125水平显著升高,上述四项血清学指标在预测孕妇胎盘早剥中具有较高的价值。
Objective To analyze the value of four serological indicators for predicting placental abruption in pregnant women,including alpha-fetoprotein(AFP),carcinoembryonic antigen 125(CA125),pregnancy-associated plasma protein-A(PAPP-A)and placental growth factor(PLGF).Methods A total of 152 pregnant women who underwent obstetrical examination in our hospital were selected from Sep.2018 to Nov.2020,pregnant women suspected of placental abruption were divided into observation group(n=91),and pregnant women who were in good maternal health were divided into control group(n=61).Then,all pregnant women were divided into placental abruption group(n=92)and non-placental abruption group(n=62)according to the results of pathological examination.The levels of serum AFP,CA125,PAPP-A and PLGF were detected in all pregnant women,the area under the receiver operating characteristic(ROC)curve(AUC)was used to analyze the value of four serological indices for predicting placental abruption in pregnant women.Results According to the results of pathological examination,89 pregnant women in the observation group had placental abruption,2 pregnant women had no placental abruption,3 pregnant women had placental abruption in the control group,58 pregnant women had no placental abruption;With the increase of placental abruption scores,AFP,CA125 levels showed an upward trend(P<0.05),PAPP-A,PLGF levels showed a downward trend(P<0.05);AFP,CA125,PAPP-A,PLGF alone and combined detection predict the AUC value of placental abruption of pregnant women are 0.670,0.786,0.749,0.763 and 0.897,respectively.The combined detection of four serological indicators predicts that the AUC value of placental abruption of pregnant women is significantly higher than independent detection(P<0.05).Conclusion The levels of serum PAPP-A and PLGF were significantly decreased in pregnant women with placental abruption,while levels of serum AFP and CA125 were significantly increased,and the above four serological indicators had a high value for predicting placental abruption in pregnant women.
作者
胡蕾蕾
HU Lei-lei(Inspection Department of Specialized Disease Hospital of Zhoukou Center for Disease Control and Prevention,Zhoukou,Henan 466000,China)
出处
《医药论坛杂志》
2021年第18期48-51,56,共5页
Journal of Medical Forum
关键词
胎盘早剥
甲胎蛋白
癌胚抗原125
妊娠相关蛋白A
胎盘生长因子
Placental abruption
Alpha-fetoprotein
Carcinoembryonic antigen 125
Pregnancy-associated plasma protein-A
Placental growth factor
