摘要
目的:观察使用消幻汤联合利培酮治疗精神分裂症(SZ)的临床效果及安全性。方法:将入选的128例SZ患者,随机分为对照组(n=64)和观察组(n=64);两组均采用抗精神病药物利培酮治疗,观察组在利培酮治疗基础上予以消幻汤辅助治疗。分别于治疗前和治疗4周后采用阳性和阴性症状量表(PANSS)、精神分裂症认知功能评定量表(SCoRS)和生活质量和满意度自评问卷(Q-LES-Q)进行评估;进行事件相关电位P300检测,采用威斯康新卡片分类测试(WSCT)评估患者认知功能;比较两组临床疗效及药物不良反应情况。结果:观察组治疗总有效率(85.94%)显著高于对照组(70.31%)。治疗后,观察组PANSS量表阴性症状评分及总分均显著低于对照组。观察组P300潜伏期缩短、波幅升高,WCST各指标除完成分类数外,其他均较治疗前明显改善,而对照组治疗前、后P300潜伏期、波幅及WCST各指标无显著改变。观察组SCoRS评分较治疗前显著下降,且明显低于对照组;两组Q-LES-Q评分均较治疗前显著增加,组间比较观察组显著高于对照组。两组总不良反应发生率(21.88%vs 18.75%)比较无显著差异。结论:消幻汤联合利培酮治疗SZ疗效确切,有助于改善患者认知功能及生活质量水平,且安全性良好。
Objective To observe the clinical curative effect and safety of Xiaohuan Decoction combined with risperidone on schizophrenia(SZ).Methods A total of 128 SZ patients were randomly divided into control group(n=64)and observation group(n=64).Both groups were treated with antipsychotic drug risperidone.On this basis,observation group was given Xiaohuan Decoction for auxiliary treatment.Before treatment and after 4 weeks of treatment,they were evaluated by positive and negative symptoms scale(PANSS),schizophrenia cognition rating scale(SCoRS)and quality of life enjoyment and satisfaction questionnaire(Q-LES-Q).The event-related potential P300 was detected.The cognitive function of patients was evaluated by Wisconsin Card Sorting Test(WSCT).The clinical curative effect and adverse drug reactions were compared between the two groups.Results The total response rate of treatment in observation group was significantly higher than that in control group(85.94%vs 70.31%).After treatment,negative symptom score and total score of PANSS in observation group were significantly lower than those in control group.In observation group,P300 latency was shortened,while wave amplitude was increased.Except for the number of completed classifications,the other indexes of WCST were significantly improved.There were no significant differences in P300 latency,wave amplitude and WCST indexes before and after treatment in control group.After treatment,SCoRS score in observation group was significantly decreased,which was significantly lower than that in control group.After treatment,Q-LES-Q scores in both groups were significantly increased,which were significantly higher in observation group than control group.There was no significant difference in the total incidence of adverse reactions between the two groups(21.88%vs 18.75%).Conclusion The curative effect of Xiaohuan Decoction combined with risperidone is significant on SZ,which is conductive to improving cognitive function and quality of life in patients,with good safety.
作者
孙玉涛
王磊
贾翠娜
徐阳
黄艳艳
Sun Yu-tao;Wang Lei;Jia Cui-na;Xu Yang;Huang Yan-yan(Fifth Hospital,Tangshan City,Hebei Province,Tangshan 063000,China)
出处
《湖南师范大学学报（医学版）》
2021年第6期31-34,共4页
Journal of Hunan Normal University(Medical Sciences)
基金
河北省2021年度医学科学研究课题计划(NO.20211102)
关键词
精神分裂症
消幻汤
利培酮
认知功能
不良反应
schizophrenia
xiaohuan decoction
risperidone
cognitive function
adverse reaction
