摘要
目的:研究Crizotinib对非小细胞肺癌裸鼠肝细胞生长因子表达及生存情况影响。方法:我们将60只裸鼠分组造模后,用不同药物灌胃给药。比较药物治疗后三组大鼠的肿瘤生长情况,分析比较三组大鼠8周生存率,采用ELISA法测定治疗前后大鼠血清HGF水平。结果:Crizotinib灌胃组裸鼠肿瘤增长速度明显降低,血清HGF水平迅速增长,生存时间延长。结论:Crizotinib可有效抑制非小细胞肺癌生长,降低血清肝细胞生长因子表达水平,提高裸鼠8周生存率,Crizotinib可有效治疗裸鼠非小细胞肺癌。
Objective To investigate the effect of Crizotinib on hepatocyte growth factor expression and survival in non-small cell lung cancer in nude mice.Methods We divided 60 nude mice into groups and then administered gavage with different drugs.The tumor growth of the three groups of rats after drug treatment was compared.The 8-week survival rate of the three groups of rats was compared.The serum HGF levels of the rats before and after treatment were determined by ELISA.Results It was found that the tumor growth rate of Crizotinib group was significantly decreased,serum HGF level increased rapidly and survival time was prolonged.Crizotinib can effectively inhibit the growth of non-small cell lung cancer,reduce the expression of serum hepatocyte growth factor,improve the survival rate of 8-week nude mice.Conclusion Crizotinib can effectively treat non-small cell lung cancer in nude mice.
作者
金岩
杨镇嘉
Jin Yan;Yang Zhen-jia(Chifeng University Affiliated Hospital Respiratory and Critical Care Medicine,Chifeng 024001,China)
出处
《湖南师范大学学报（医学版）》
2021年第4期117-120,共4页
Journal of Hunan Normal University(Medical Sciences)
